内科学(腎臓・内分泌・代謝)

研究成果

年別の研究成果 1993 2011 2012 2014 2015 2016 2018 2019 2020 2021 2022 2023 2024

• 522 Article
• 68 Review article
• 20 Comment/debate
• 14 Letter
• 24 その他
  • 13 Editorial
  • 6 Chapter
  • 5 Short survey

年別の研究成果

年別の研究成果

検索結果

• 2008

  Differential effects of transient treatment of spontaneously hypertensive rats with various antihypertensive agents on the subsequent development of diabetic nephropathy

  Ishiguro, K., Sasamura, H., Sakamaki, Y., Hayashi, K., Saruta, T. & Itoh, H., 2008 6月, In: Nephron - Experimental Nephrology. 109, 1, p. e20-e28

  研究成果: Article › 査読

  • Diabetic Nephropathy 100%
  • Angiotensin Receptor Antagonist 100%
  • Antihypertensive Agent 100%
  • Spontaneously Hypertensive Rat 100%
  • Mineralocorticoid Antagonist 71%
  8 被引用数 (Scopus)

• Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension

  Komiya, N., Hirose, H., Saisho, Y., Saito, I. & Itoh, H., 2008, In: International Heart Journal. 49, 6, p. 681-689 9 p.

  研究成果: Article › 査読

  • Valsartan 100%
  • Diabetic Subjects 100%
  • Glycation Stress 100%
  • 8-isoprostane 28%
  • 8 Isoprostane 28%
  25 被引用数 (Scopus)

• Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetes

  Kawai, T., Funae, O., Shimada, A., Tabata, M., Hirata, T., Atsumi, Y. & Itoh, H., 2008, In: Internal Medicine. 47, 13, p. 1181-1188 8 p.

  研究成果: Article › 査読

  • Low Drug Dose 100%
  • Pioglitazone 100%
  • Non Insulin Dependent Diabetes Mellitus 100%
  • Metformin 100%
  • Metabolic Weight 100%
  14 被引用数 (Scopus)

• Hyperplastic islets observed in "reversed" NOD mice treated without hematopoietic cells

  Okubo, Y., Shimada, A., Kanazawa, Y., Shigihara, T., Oikawa, Y., Imai, T., Miyazaki, J. & Itoh, H., 2008 1月 1, In: Diabetes Research and Clinical Practice. 79, 1, p. 18-23 6 p.

  研究成果: Article › 査読

  • Beta Cell 100%
  • Hematopoietic Stem Cell 100%
  • Ob/Ob Mouse 100%
  • Autoimmune Diabetes 100%
  • Mouse 100%
  7 被引用数 (Scopus)

• Methodology for assessment of renal function

  Hayashi, K., Wakino, S. & Tokuyama, H., 2008 9月, In: Nippon rinsho. Japanese journal of clinical medicine. 66, 9, p. 1719-1722 4 p.

  研究成果: Review article › 査読

  • Fatty Acid Binding Protein 100%
  • Glomerulus Filtration 25%
  • Cystatin C 25%
  • Protein Z 25%
  • Fatty Acid-Binding Protein 25%
  3 被引用数 (Scopus)

• Obesity in CKD

  Tokuyama, H., Wakino, S. & Ito, H., 2008 9月, In: Nippon rinsho. Japanese journal of clinical medicine. 66, 9, p. 1770-1777 8 p.

  研究成果: Review article › 査読

  • Lipid Diet 100%
  • Adipose Tissue 49%
  • Nephritic Syndrome 49%
  • Elevated Blood Pressure 49%
  • Functional Change 42%
  2 被引用数 (Scopus)

• Pathologic roles of prorenin and (pro)renin receptor in the eye

  Satofuka, S., Ichihara, A., Nagai, N., Tsubota, K., Itoh, H. & Ishida, S., 2008, In: Frontiers in Bioscience. 13, 10, p. 3884-3895 12 p.

  研究成果: Review article › 査読

  • Prosegment 100%
  • Ocular Neovascularization 100%
  • Eye Inflammation 87%
  • Neovascularization (Pathology) 87%
  • Angiotensin II Receptor Type 1 87%
  18 被引用数 (Scopus)

• Renal cytochrome P450 as a determinant of impaired natriuresis by PPAR-γ ligands in ovariectomized obese rats

  Yoshioka, K., Wakino, S., Homma, K., Kanda, T., Tatematsu, S., Hasegawa, K., Sugano, N., Ito, O., Omata, K., Saruta, T. & Hayashi, K., 2008 5月, In: Obesity. 16, 5, p. 965-971 7 p.

  研究成果: Article › 査読

  • Cytochrome P450 4A 100%
  • OVX Rats 100%
  • Cyclooxygenase-1/2 20%
  • Renal Sodium Handling 20%
  • Ovariectomized (OVX) Rats 20%
  9 被引用数 (Scopus)

• Renin/prorenin receptor, (P)RR, in end-organ damage: current issues in 2007

  Inagami, T., Nakagawa, T., Ichihara, A., Suzuki, F. & Itoh, H., 2008 7月, In: Journal of the American Society of Hypertension. 2, 4, p. 205-209 5 p.

  研究成果: Review article › 査読

  • Receptor 100%
  • Prorenin Receptor 100%
  • Renin 100%
  • Diabetes Mellitus 80%
  • Prorenin 80%
  4 被引用数 (Scopus)

• Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

  Hasegawa, K., Wakino, S., Yoshioka, K., Tatematsu, S., Hara, Y., Minakuchi, H., Washida, N., Tokuyama, H., Hayashi, K. & Itoh, H., 2008 7月 18, In: Biochemical and Biophysical Research Communications. 372, 1, p. 51-56 6 p.

  研究成果: Article › 査読

  • Tubular Cell Apoptosis 100%
  • Bidirectional Regulation 100%
  • H2O2-induced Apoptosis 20%
  • Protein Deacetylase 14%
  • NAD+-dependent 10%
  211 被引用数 (Scopus)

• The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia

  Oyamada, N., Sone, M., Miyashita, K., Park, K., Taura, D., Inuzuka, M., Sonoyama, T., Tsujimoto, H., Fukunaga, Y., Tamura, N., Itoh, H. & Nakao, K., 2008 8月, In: Endocrinology. 149, 8, p. 3764-3777 14 p.

  研究成果: Article › 査読

  • Receptor Expression 100%
  • Mineralocorticoid Receptor 100%
  • Cerebral Ischemia 100%
  • Brain Reorganization 100%
  • Brain Ischemia 100%
  54 被引用数 (Scopus)

• T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy

  Sugano, N., Wakino, S., Kanda, T., Tatematsu, S., Homma, K., Yoshioka, K., Hasegawa, K., Hara, Y., Suetsugu, Y., Yoshizawa, T., Hara, Y., Utsunomiya, Y., Tokudome, G., Hosoya, T., Saruta, T. & Hayashi, K., 2008 4月, In: Kidney international. 73, 7, p. 826-834 9 p.

  研究成果: Article › 査読

  • Calcium Channel Blockade 100%
  • T-type Calcium Channel 100%
  • Renal Injury 100%
  • Subtotal Nephrectomy 100%
  • Calcium Channel T Type 100%
  44 被引用数 (Scopus)
• 2007

  Add-on amlodipine improves arterial function and structure in hypertensive patients treated with an angiotensin receptor blocker

  Ichihara, A., Kaneshiro, Y., Sakoda, M., Takemitsu, T. & Itoh, H., 2007 3月, In: Journal of Cardiovascular Pharmacology. 49, 3, p. 161-166 6 p.

  研究成果: Article › 査読

  • Angiotensin Receptor Antagonist 100%
  • Amlodipine 100%
  • Angiotensin Receptor 100%
  • Arterial Function 100%
  • Ambulatory Blood Pressure 42%
  34 被引用数 (Scopus)

• Ca2+ channel subtypes and pharmacology in the kidney

  Hayashi, K., Wakino, S., Sugano, N., Ozawa, Y., Homma, K. & Saruta, T., 2007 2月, In: Circulation research. 100, 3, p. 342-353 12 p.

  研究成果: Review article › 査読

  • Calcium Channel 100%
  • Channel Blocker 31%
  • Tubular Tissue 20%
  • Microcirculation 12%
  • Nifedipine 12%
  208 被引用数 (Scopus)

• Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9

  Yokota, K., Shibata, H., Kurihara, I., Kobayashi, S., Suda, N., Murai-Takeda, A., Saito, I., Kitagawa, H., Kato, S., Saruta, T. & Itoh, H., 2007 1月 19, In: Journal of Biological Chemistry. 282, 3, p. 1998-2010 13 p.

  研究成果: Article › 査読

  • N-Terminus 100%
  • Mineralocorticoid Receptor 100%
  • Transactivation 100%
  • Nuclear Receptor Coactivator 1 18%
  • Enzyme 12%
  68 被引用数 (Scopus)

• Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury

  Ishiguro, K., Sasamura, H., Sakamaki, Y., Itoh, H. & Saruta, T., 2007 1月, In: Hypertension Research. 30, 1, p. 63-75 13 p.

  研究成果: Article › 査読

  • Kidney Injury 100%
  • Renin 100%
  • Angiotensin 100%
  • Development Activities 100%
  • L-NAME Hypertension 100%
  45 被引用数 (Scopus)

• High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men

  Seino, Y., Hirose, H., Saito, I. & Itoh, H., 2007 11月, In: Metabolism: clinical and experimental. 56, 11, p. 1493-1499 7 p.

  研究成果: Article › 査読

  • Metabolic Syndrome 100%
  • Adiponectin 100%
  • Polymer 100%
  • Metabolic Syndrome X 100%
  • Insulin Resistance 100%
  101 被引用数 (Scopus)

• Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjects

  Saisho, Y., Maruyama, T., Hirose, H. & Saruta, T., 2007 11月 1, In: Diabetes Research and Clinical Practice. 78, 2, p. 182-188 7 p.

  研究成果: Article › 査読

  • Advanced Glycation End Product 100%
  • Proinsulin 100%
  • Glycation 50%
  • 8 Isoprostane 12%
  • Chemiluminescent Enzyme Immunoassay (CLEIA) 12%
  20 被引用数 (Scopus)

• Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2

  Hasegawa, K., Wakino, S., Tatematsu, S., Yoshioka, K., Homma, K., Sugano, N., Kimoto, M., Hayashi, K. & Itoh, H., 2007 7月, In: Circulation research. 101, 2, p. e2-e10

  研究成果: Article › 査読

  • Blood Pressure 100%
  • Transgenic Mouse 100%
  • 6 N,n' Dimethylarginine 100%
  • N(g),n(g) Dimethylarginine 100%
  • Blood Vessel Injury 100%
  114 被引用数 (Scopus)

• Snail1 is involved in the renal epithelial-mesenchymal transition

  Yoshino, J., Monkawa, T., Tsuji, M., Inukai, M., Itoh, H. & Hayashi, M., 2007 10月 12, In: Biochemical and Biophysical Research Communications. 362, 1, p. 63-68 6 p.

  研究成果: Article › 査読

  • Mesenchymal-Epithelial Transition 100%
  • Glycogen Synthase Kinase 3 100%
  • Messenger RNA 25%
  • Transcription 25%
  • Transcription Factors 25%
  73 被引用数 (Scopus)

• The (Pro)Renin Receptor and the Kidney

  Ichihara, A., Kaneshiro, Y., Takemitsu, T., Sakoda, M. & Itoh, H., 2007 9月, In: Seminars in Nephrology. 27, 5, p. 524-528 5 p.

  研究成果: Article › 査読

  • (pro)renin Receptor 100%
  • Kidney 100%
  • Prorenin 100%
  • Eicosanoid Receptor 100%
  • Renin 100%
  55 被引用数 (Scopus)

• Use of angiotensin receptor blockers (ARBs) in the metabolic syndrome

  Sasamura, H. & Itoh, H., 2007 2月, In: Nippon rinsho. Japanese journal of clinical medicine. 65, 2, p. 381-388 8 p.

  研究成果: Review article › 査読

  • Metabolic Syndrome 100%
  • Angiotensin Receptor Antagonist 100%
  • Metabolic Syndrome X 100%
  • Angiotensin Receptor 100%
  • Early Intervention 50%
• 2006

  Case studies: Reducing risk in patients with diabetes

  Komajda, M., Erdmann, E., Komuro, I., Schernthaner, G., Itoh, H. & Matsuzaki, M., 2006 12月, In: Drugs of Today. 42, SUPPL. C, p. 37-41 5 p.

  研究成果: Article › 査読
  1 被引用数 (Scopus)

• Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells

  Hasegawa, K., Wakino, S., Tanaka, T., Kimoto, M., Tatematsu, S., Kanda, T., Yoshioka, K., Homma, K., Sugano, N., Kurabayashi, M., Saruta, T. & Hayashi, K., 2006 7月, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 7, p. 1488-1494 7 p.

  研究成果: Article › 査読

  • Vascular Endothelial Growth Factor 100%
  • Sp1 Transcription Factor 100%
  • Dimethylargininase 100%
  • Vasculotropin 100%
  • Transcription Factor Sp1 100%
  77 被引用数 (Scopus)

• Metabolic domino: New concept in lifestyle medicine

  Itoh, H., 2006 12月 1, In: Drugs of Today. 42, SUPPL. C, p. 9-16 8 p.

  研究成果: Review article › 査読

  • Medicine 100%
  • Diabetes 100%
  • Cardiovascular System 100%
  • Pioglitazone 100%
  • Lifestyle Medicine 100%
  17 被引用数 (Scopus)

• Molecular mechanisms and therapeutic strategies of chronic renal injury: Role of rho-kinase in the development of renal injury

  Hayashi, K., Wakino, S., Kanda, T., Homma, K., Sugano, N. & Saruta, T., 2006, In: Journal of Pharmacological Sciences. 100, 1, p. 29-33 5 p.

  研究成果: Short survey › 査読

  • Kidney Injury 100%
  • Rho Kinase 100%
  • Chronic Renal Injury 100%
  • Angiotensin II 40%
  • Fasudil 40%
  35 被引用数 (Scopus)

• Primary malignant hepatic pheochromocytoma with negative adrenal scintigraphy

  Homma, K., Hayashi, K., Wakino, S., Irie, R., Mukai, M., Kumagai, H., Shibata, H. & Saruta, T., 2006 7月, In: Hypertension Research. 29, 7, p. 551-554 4 p.

  研究成果: Article › 査読

  • Primary Malignant 100%
  • Drainage Vein 33%
  • Normetanephrine 33%
  7 被引用数 (Scopus)

• Rho-kinase as a molecular target for insulin resistance and hypertension

  Kanda, T., Wakino, S., Homma, K., Yoshioka, K., Tatematsu, S., Hasegawa, K., Takamatsu, I., Sugano, N., Hayashi, K. & Saruta, T., 2006 1月 1, In: FASEB Journal. 20, 1, p. 169-171 3 p.

  研究成果: Article › 査読
  93 被引用数 (Scopus)
• 2005

  A case of severe heat stroke with abnormal cardiac findings

  Wakino, S., Hori, S., Mimura, T., Miyatake, S., Fujishima, S. & Aikawa, N., 2005 7月 26, In: International Heart Journal. 46, 3, p. 543-550 8 p.

  研究成果: Article › 査読

  • Heat Stroke 100%
  • Cardiac Findings 100%
  • Myocardial Markers 100%
  • Myocardial Infarction 100%
  • Central Nervous System 100%
  23 被引用数 (Scopus)

• Anti-hypertensive effects of PPARgamma ligands through the inhibition of Rho/Rho kinase pathway

  Wakino, S. & Hayashi, K., 2005 4月, In: Nippon rinsho. Japanese journal of clinical medicine. 63, 4, p. 693-699 7 p.

  研究成果: Review article › 査読

  • Antihypertensive Agent 100%
  • Hypertension 100%
  • Rho Kinase 100%
  • PPARgamma 100%
  • Pioglitazone 40%
  3 被引用数 (Scopus)

• Divergent action of calcium channel blockers on ATP-binding cassette protein expression

  Hasegawa, K., Wakino, S., Kanda, T., Yoshioka, K., Tatematsu, S., Homma, K., Takamatsu, I., Sugano, N. & Hayashi, K., 2005 12月 1, In: Journal of Cardiovascular Pharmacology. 46, 6, p. 787-793 7 p.

  研究成果: Article › 査読

  • Protein Expression 100%
  • Calcium Channel Blockers 100%
  • ATP-binding Cassette Transporter A1 (ABCA1) 100%
  • ABC Transporter A1 87%
  • Aranidipine 50%
  11 被引用数 (Scopus)

• Effect of switching from NPH insulin to insulin glargine on glycemic control in Japanese type 1 diabetic patients

  Saisho, Y., Maruyama, T., Imai, T., Shimada, A. & Suzuki, Y., 2005, In: Journal of the Japan Diabetes Society. 48, 9, p. 685-691 7 p.

  研究成果: Article › 査読

  • Glycemic Control 100%
  • Hemoglobin A1c (HbA1c) 100%
  • Type 1 Diabetic Patient 100%
  • Insulin Glargine 100%
  • NPH Insulin 100%
  2 被引用数 (Scopus)

• Heat stroke with multiple organ failure treated with cold hemodialysis and cold continuous hemodiafiltration: A case report

  Wakino, S., Hori, S., Mimura, T., Fujishima, S., Hayashi, K., Inamoto, H., Saruta, T. & Aikawa, N., 2005 10月, In: Therapeutic Apheresis and Dialysis. 9, 5, p. 423-428 6 p.

  研究成果: Article › 査読

  • Heat Stroke 100%
  • Body Temperature 100%
  • Continuous Hemodiafiltration 100%
  • Mild Hepatic Impairment 50%
  • Emergency Rooms 50%
  24 被引用数 (Scopus)

• Pathophysiological significance of T-type Ca²⁺ channels: Role of T-type Ca²⁺ channels in renal microcirculation

  Hayashi, K., Wakino, S., Homma, K., Sugano, N. & Saruta, T., 2005, In: Journal of Pharmacological Sciences. 99, 3, p. 221-227 7 p.

  研究成果: Article › 査読

  • Microcirculation 100%
  • Calcium Channel 100%
  • Arteriole 66%
  • Hemodynamic 33%
  • Nifedipine 33%
  46 被引用数 (Scopus)

• Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats

  Wakino, S., Hayashi, K., Tatematsu, S., Hasegawa, K., Takamatsu, I., Kanda, T., Homma, K., Yoshioka, K., Sugano, N. & Saruta, T., 2005 3月, In: Hypertension Research. 28, 3, p. 255-262 8 p.

  研究成果: Article › 査読

  • 6 N,n' Dimethylarginine 100%
  • N(g),n(g) Dimethylarginine 100%
  • Dimethylargininase 100%
  • Pioglitazone 100%
  • Asymmetric Dimethylarginine 100%
  104 被引用数 (Scopus)

• Pulmonary tuberculosis and adenovirus-hemorrhagic cystitis after autologous peripheral blood stem cell transplantation for follicular lymphoma

  Iguchi, T., Yokoyama, K., Mitsuishi, M., Chen, C. K., Ikeda, Y. & Okamoto, S., 2005 9月, In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 46, 9, p. 1049-1054 6 p.

  研究成果: Article › 査読

  • Hemorrhagic Cystitis 100%
  • Trimethoprim/Sulfamethoxazole 33%
  • Pyrazinamide 33%
  6 被引用数 (Scopus)

• Rho/Rho kinase as a potential target for the treatment of renal disease

  Wakino, S., Kanda, T. & Hayashi, K., 2005 12月, In: Drug News and Perspectives. 18, 10, p. 639-643 5 p.

  研究成果: Review article › 査読

  • Renal Disease 100%
  • Rho Kinase 100%
  • Kidney Disease 100%
  • Rho Kinase Inhibitor 33%
  • Kidney Injury 33%
  24 被引用数 (Scopus)

• Role of asymmetrical dimethylarginine in renal microvascular endothelial dysfunction in chronic renal failure with hypertension

  Okubo, K., Hayashi, K., Wakino, S., Matsuda, H., Kubota, E., Honda, M., Tokuyama, H., Yamamoto, T., Kajiya, F. & Saruta, T., 2005 2月, In: Hypertension Research. 28, 2, p. 181-189 9 p.

  研究成果: Article › 査読

  • Hypertension 100%
  • Asymmetric Dimethylarginine 100%
  • Chronic Kidney Disease 100%
  • Vascular Endothelial Dysfunction 100%
  • Acetylcholine 100%
  46 被引用数 (Scopus)

• Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats - Studies in the isolated perfused hydronephrotic kidney

  Hayashi, K., Wakino, S., Ozawa, Y., Homma, K., Kanda, T., Okubo, K., Takamatsu, I., Tatematsu, S., Kumagai, H. & Saruta, T., 2005 6月, In: Keio Journal of Medicine. 54, 2, p. 102-108 7 p.

  研究成果: Article › 査読

  • Spontaneously Hypertensive Rat 100%
  • Calcium Channel 100%
  • Protein Kinase C 100%
  • Channel Blocker 100%
  • Rat Study 100%
  2 被引用数 (Scopus)

• Role of Rho-kinase and p27 in angiotensin II-induced vascular injury

  Kanda, T., Hayashi, K., Wakino, S., Homma, K., Yoshioka, K., Hasegawa, K., Sugano, N., Tatematsu, S., Takamatsu, I., Mitsuhashi, T. & Saruta, T., 2005 4月, In: Hypertension. 45, 4 SUPPL., p. 724-729 6 p.

  研究成果: Article › 査読

  • Angiotensin II (Ang II) 100%
  • Rho Kinase 100%
  • Vascular Injury 100%
  • Mouse 100%
  • Wild Type Mouse 100%
  53 被引用数 (Scopus)

• Spontaneous multiple arterial dissections presenting with renal infarction and subarachnoid hemorrhage in a patient under treatment for infertility

  Wakino, S., Tawarahara, K., Tsuchiya, N., Kurosawa, Y., Sugihara, T. & Ando, K., 2005 3月, In: Circulation Journal. 69, 3, p. 368-372 5 p.

  研究成果: Article › 査読

  • Subarachnoid Hemorrhage 100%
  • Vertebral Artery Dissection 100%
  • Kidney Infarction 100%
  • Arterial Dissection 100%
  • Spontaneous Arterial Dissection 50%
  11 被引用数 (Scopus)

• Ubc9 and protein inhibitor of activated STAT 1 activate chicken ovalbumin upstream promoter-transcription factor I-mediated human CYP11B2 gene transcription

  Kurihara, I., Shibata, H., Kobayashi, S., Suda, N., Ikeda, Y., Yokota, K., Murai, A., Saito, I., Rainey, W. E. & Saruta, T., 2005 2月 25, In: Journal of Biological Chemistry. 280, 8, p. 6721-6730 10 p.

  研究成果: Article › 査読

  • Protein Inhibitor of Activated STAT 100%
  • PIAS1 61%
  • Sumoylation 14%
  • Glomerulosa Cell 14%
  • Adrenal Zona Glomerulosa 7%
  46 被引用数 (Scopus)
• 2004

  Beneficial action of candesartan cilexetil plus amlodipine or ACE inhibitors in chronic nondiabetic renal disease

  Homma, K., Hayashi, K., Kanda, T., Yoshioka, K., Takamatsu, I., Tatematsu, S., Kumagai, H., Wakino, S. & Saruta, T., 2004 12月, In: Journal of Human Hypertension. 18, 12, p. 879-884 6 p.

  研究成果: Article › 査読

  • Candesartan Cilexetil 100%
  • Amlodipine 100%
  • Diabetic Kidney Disease 100%
  • Angiotensin Receptor Blockers 100%
  • ACE Inhibitors 100%
  12 被引用数 (Scopus)

• COUP-TF and transcriptional co-regulators in adrenal steroidogenesis

  Shibata, H., Kobayashi, S., Kurihara, I., Suda, N., Yokota, K., Murai, A., Ikeda, Y., Saito, I., Rainey, W. E. & Saruta, T., 2004 12月 1, In: Endocrine Research. 30, 4, p. 795-801 7 p.

  研究成果: Article › 査読

  • Transcriptional Repressor 100%
  • Transcription Factor 100%
  • COUP-TFII 100%
  • Chicken Ovalbumin 100%
  • Adrenal Steroidogenesis 100%
  17 被引用数 (Scopus)

• FHL2, UBC9, and PIAS1 are novel estrogen receptor α-interacting proteins

  Kobayashi, S., Shibata, H., Yokota, K., Suda, N., Murai, A., Kurihara, I., Saito, I. & Saruta, T., 2004, In: Endocrine Research. 30, 4, p. 617-621 5 p.

  研究成果: Article › 査読

  • FHL2 100%
  • LIM-only Protein 7%
  • Terminal Ligand 7%
  • Promoter-specific 7%
  • B Domain 7%
  42 被引用数 (Scopus)

• Free Radical Activity Depends on Underlying Vasoconstrictors in Renal Microcirculation

  Ozawa, Y., Hayashi, K., Wakino, S., Kanda, T., Homma, K., Takamatsu, I., Tatematsu, S., Yoshioka, K. & Saruta, T., 2004 4月 1, In: Clinical and Experimental Hypertension. 26, 3, p. 219-229 11 p.

  研究成果: Article › 査読

  • Vasodilator 100%
  • Renal Microcirculation 100%
  • Constriction 100%
  • Free Radical Activity 100%
  • Free Radical 100%
  20 被引用数 (Scopus)

• GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9

  Itoh, A., Shimada, A., Kodama, K., Morimoto, J., Suzuki, R., Oikawa, Y., Irie, J., Nakagawa, Y., Shigihara, T., Kanazawa, Y., Okubo, Y., Motohashi, Y., Maruyama, T. & Saruta, T., 2004, In: Annals of the New York Academy of Sciences. 1037, p. 33-40 8 p.

  研究成果: Article › 査読

  • Type 1 Diabetes Mellitus (T1DM) 100%
  • Autoreactive T Cells 100%
  • Autoimmune 100%
  • Type 1 Diabetic Patient 100%
  • T Cell 100%
  11 被引用数 (Scopus)

• Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats

  Ozawa, Y., Hayashi, K., Kanda, T., Homma, K., Takamatsu, I., Tatematsu, S., Yoshioka, K., Kumagai, H., Wakino, S. & Saruta, T., 2004 10月, In: Nephrology. 9, 5, p. 272-277 6 p.

  研究成果: Article › 査読

  • Endothelium Derived Hyperpolarizing Factor 100%
  • Dahl Salt Sensitive Rat 100%
  • Endothelium-Derived Hyperpolarizing Factor 100%
  • Tempol 33%
  • Salt-resistant 22%
  14 被引用数 (Scopus)

• Insulin-like growth factor-1 (IGF-1)-derived peptide protects against diabetes in NOD mice

  Kodama, K., Shimada, A., Funae, O., Morimoto, J., Irie, J., Shigihara, T., Oikawa, Y., Tokui, M., Watanabe, K. & Saruta, T., 2004 9月, In: Autoimmunity. 37, 6-7, p. 481-487 7 p.

  研究成果: Article › 査読

  • Glutamate Decarboxylase 100%
  • Type 1 Diabetes Management 100%
  • Cell Destruction 50%
  • Insulitis 50%
  • Intracellular Cytokine Assay 50%
  5 被引用数 (Scopus)

• N-acetyl-cysteine accelerates transfer of diabetes into non-obese diabetic scid mice

  Irie, J., Shimada, A., Oikawa, Y., Shigihara, T. & Saruta, T., 2004 10月, In: Diabetologia. 47, 10, p. 1803-1809 7 p.

  研究成果: Article › 査読

  • Mouse 100%
  • Pancreas 100%
  • Acetylcysteine 100%
  • Diabetic Obesity 100%
  • Splenocyte 75%
  6 被引用数 (Scopus)