内科学(リウマチ・膠原病)

2025

Association of methotrexate polyglutamates concentration with methotrexate efficacy and safety in patients with rheumatoid arthritis treated with predefined dose: results from the MIRACLE trial

MIRACLE Study Group, 2025 1月, In: Annals of the rheumatic diseases. 84, 1, p. 41-48 8 p.

研究成果: Article › 査読

CCR4+Tfh2 cells specifically produce IL-4 driving the pathological reaction in IgG4-related disease

Akiyama, M., Yoshimoto, K., Yasuoka, H., Ishigaki, S., Takanashi, S., Takeuchi, T. & Kaneko, Y., 2025 3月, In: Clinical and experimental rheumatology. 43, 3, p. 435-443 9 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Clinical Images: Propylthiouracil-induced antineutrophil cytoplasmic antibody–associated vasculitis with aortic wall thickening

Ishigaki, S., Kikuchi, J. & Kaneko, Y., 2025 1月, In: ACR Open Rheumatology. 7, 1, e11786.

研究成果: Article › 査読

Open Access

Contrast of muscle magnetic resonance imaging and pathological findings of muscle tissue in patients with anti-aminoacyl transfer RNA synthetase antibodies

Takei, H., Kondo, Y., Takanashi, S., Takeuchi, T., Matsubara, S. & Kaneko, Y., 2025 3月 1, In: Modern rheumatology. 35, 2, p. 307-313 7 p.

研究成果: Article › 査読

CX3CR1⁺ age-associated CD4⁺ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis

Akiyama, M., Wakasugi, S., Yoshimoto, K., Saito, K., Ishigaki, S., Inukai, R., Matsuno, Y., Alshehri, W., Kondo, Y. & Kaneko, Y., 2025 12月, In: Inflammation and Regeneration. 45, 1, 4.

研究成果: Article › 査読

1 被引用数 (Scopus)

Cytotoxic CX3CR1+ T cells drive vascular inflammation in giant cell arteritis but not in Takayasu’s arteritis

Inukai, R., Akiyama, M., Yoshimoto, K., Wakasugi, S., Matsuno, Y., Ishigaki, S., Alshehri, W., Saito, K. & Kaneko, Y., 2025 4月, In: Clinical and experimental rheumatology. 43, 4, p. 630-635 6 p.

研究成果: Article › 査読

Dapagliflozin for rheumatic musculoskeletal disease in patients with chronic kidney disease

Hanaoka, H., Kikuchi, J., Hiramoto, K., Akiyama, M., Saito, S., Kondo, Y., Azegami, T. & Kaneko, Y., 2025 3月 1, In: Modern rheumatology. 35, 2, p. 345-351 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Five-year follow-up of patients with difficult-to-treat rheumatoid arthritis

Takanashi, S., Takeuchi, T. & Kaneko, Y., 2025 5月 1, In: Rheumatology. 64, 5, p. 2487-2495 9 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity

Biobank Japan Project & Japan COVID-19 Task Force, 2025 3月 12, In: Cell Genomics. 5, 3, 100783.

研究成果: Article › 査読

Identification of BHLHE40-Expressing CD4⁺ T Cells Producing GM-CSF in Rheumatoid Arthritis

Ishigaki, S., Suzuki, K., Takeshita, M. & Kaneko, Y., 2025 4月, In: International Journal of Rheumatic Diseases. 28, 4, e70219.

研究成果: Article › 査読

Protocol: Filgotinib in addition to methotrexate versus filgotinib monotherapy in patients with rheumatoid arthritis with an inadequate response to methotrexate: A multicenter, prospective, open-label, randomized controlled trial (FAITHFUL Study)

Akiyama, M., Hidaka, T., Kaneko, M., Ito, S., Taguchi, H., Ishii, T., Asai, S., Hirata, S., Ikeda, K., Suzuki, K., Kato, N. & Kaneko, Y., 2025 5月, In: PloS one. 20, 5 May, e0322621.

研究成果: Article › 査読

Radiological extent predicts prognosis and relapse after acute exacerbation of interstitial lung disease in patients with rheumatoid arthritis: KEIO-RA-cohort

Suzuki, K., Akiyama, M., Shimanuki, K. & Kaneko, Y., 2025 4月, In: Rheumatology International. 45, 4, 92.

研究成果: Article › 査読

Risk factors for adverse drug reactions to sulfamethoxazole-trimethoprim prophylaxis in patients with rheumatic and musculoskeletal diseases

Hiramoto, K., Akiyama, M. & Kaneko, Y., 2025 1月 1, In: Modern rheumatology. 35, 1, p. 94-101 8 p.

研究成果: Article › 査読

Open Access

Successful maintenance therapy with tocilizumab for severe acute liver failure associated with adult-onset still’s disease

Suzuki, K., Akiyama, M., Nakadai, Y., Usui, S. & Kaneko, Y., 2025, In: Immunological Medicine. 48, 1, p. 89-93 5 p.

研究成果: Article › 査読

Open Access

Tense blisters and haemorrhagic bullae as the first manifestation of eosinophilic granulomatosis with polyangiitis

Inokuchi, H., Akiyama, M., Horikawa, H., Kondo, Y., Saito, S., Kikuchi, J., Hanaoka, H. & Kaneko, Y., 2025 1月 1, In: Modern Rheumatology Case Reports. 9, 1, p. 149-154 6 p.

研究成果: Article › 査読

Open Access

Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis

Hiramoto, K., Saito, S., Hanaoka, H., Kikuchi, J., Fukui, H., Hashiguchi, A., Suzuki, K., Takeuchi, T. & Kaneko, Y., 2025 3月, In: Arthritis and Rheumatology. 77, 3, p. 298-310 13 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

2024

Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank

Loganathan, A., Zanframundo, G., Yoshida, A., Faghihi-Kashani, S., Ventura, I. B., Dourado, E., Bozan, F., Sambataro, G., Yamano, Y., Bae, S. S., Lim, D., Ceribelli, A., Isailovic, N., Selmi, C., Fertig, N., Bravi, E., Kaneko, Y., Saraiva, A. P., Jovani, V. & Bachiller-Corral, J. & 39 others, Cifrian, J., Mera-Varela, A., Moghadam-Kia, S., Wolff, V., Campagne, J., Meyer, A., Giannini, M., Triantafyllias, K., Knitza, J., Gupta, L., Molad, Y., Iannone, F., Cavazzana, I., Piga, M., De Luca, G., Tansley, S., Bozzalla-Cassione, E., Bonella, F., Corte, T. J., Doyle, T. J., Fiorentino, D., Gonzalez-Gay, M. A., Hudson, M., Kuwana, M., Lundberg, I. E., Mammen, A. L., McHugh, N. J., Miller, F. W., Montecucco, C., Oddis, C. V., Rojas-Serrano, J., Schmidt, J., Scirè, C. A., Callaghan, A. S. O., Werth, V. P., Alpini, C., Bozzini, S., Cavagna, L. & Aggarwal, R., 2024 2月, In: Clinical and experimental rheumatology. 42, 2, p. 277-287 11 p.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

A Preliminary Survey of Rheumatologists on the Management of Late-onset Rheumatoid Arthritis in Japan

Takanashi, S., Kaneko, Y., Kawahito, Y., Kida, T., Sugihara, T., Kojima, T., Harada, R., Ishitoku, M., Hirata, S., Hashimoto, M., Hidaka, T., Abe, A., Ishikawa, H., Ito, H., Kishimoto, M., Matsui, K., Matsui, T., Matsushita, I., Onishi, A. & Morinobu, A. & 5 others, Nishida, K., Asai, S., Tanaka, E., Harigai, M. & Kojima, M., 2024, In: Internal Medicine. 63, 24, p. 3299-3306 8 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Apremilast is a potentially useful treatment for severe palmoplantar pustulosis with extra-palmoplantar symptoms

Fukushima-Nomura, A., Takamiyagi, S., Kakuta, R., Ito, Y., Hirai, I., Umemoto, J., Hanaoka, H., Kaneko, Y. & Tanese, K., 2024 4月, In: Skin Health and Disease. 4, 2, e336.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Association of sustained lupus low disease activity state with improved outcomes in systemic lupus erythematosus: a multinational prospective cohort study

Asia-Pacific Lupus Collaboration, 2024 8月, In: The Lancet Rheumatology. 6, 8, p. e528-e536

研究成果: Article › 査読

9 被引用数 (Scopus)

Clinical and immunological effects of hydroxychloroquine in patients with active rheumatoid arthritis despite antirheumatic treatment

Takei, H., Takanashi, S., Otomo, K., Hanaoka, H., Kikuchi, J., Yamaoka, K., Yoshimoto, K., Abe, T., Takeuchi, T. & Kaneko, Y., 2024 1月 1, In: Modern rheumatology. 34, 1, p. 50-59 10 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Clinical relevance of proteinuria selectivity index and fractional excretion of sodium in patients with nephrotic syndrome

Nakayama, T., Azegami, T., Yamaguchi, S., Hirano, K., Komatsu, M., Fujii, K., Futatsugi, K., Urai, H., Kawaguchi, T., Itoh, T., Yoshimoto, N., Hagiwara, A., Hishikawa, A., Matsuda, H., Ando, T., Yamaji, Y., Murakami, M., Hashiguchi, A., Kaneko, Y. & Yokoo, T. & 1 others, Hayashi, K., 2024 12月, In: Scientific reports. 14, 1, 23755.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Comparison between the BioPlex 2200 ANA Screen™ and a conventional method with respect to the detection of autoantibodies

Kaneko, Y., Saito, S., Kojima, M., Oshige, T., Ota, Y., Nishina, N., Kikuchi, J., Hanaoka, H. & Takeuchi, T., 2024 7月 1, In: Modern rheumatology. 34, 4, p. 864-865 2 p.

研究成果: Article › 査読

Open Access

Consensus statement on the management of late-onset rheumatoid arthritis

LORIS Study Collaborators, 2024 11月 1, In: Modern rheumatology. 34, 6, p. 1095-1102 8 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey

COVAD Study Group, 2024 1月, In: Rheumatology International. 44, 1, p. 89-97 9 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

COVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group

COVAD Study Group, 2024 1月, In: Rheumatology International. 44, 1, p. 73-80 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

COVID-19 severity, breakthrough infections and vaccine safety in young individuals with autoimmune diseases: insights from the COVAD study

COVAD Study Group, 2024 9月, In: Rheumatology International. 44, 9, p. 1725-1731 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

COVID-19 vaccine safety during pregnancy and breastfeeding in women with autoimmune diseases: Results from the COVAD study

behalf of COVAD Study Group, 2024 5月 1, In: Rheumatology. 63, 5, p. 1341-1351 11 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

Seki, N., Tsujimoto, H., Tanemura, S., Kojima, S., Miyoshi, F., Kikuchi, J., Saito, S., Akiyama, M., Sugahara, K., Yoshimoto, K., Kaneko, Y., Chiba, K. & Takeuchi, T., 2024 12月, In: Communications biology. 7, 1, 277.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Development of quality indicators for pregnancy and childbirth in patients with systemic lupus erythematosus

Hatano, M., Yajima, N., Yanai, R., Ishii, S., Tsujimoto, Y., Azuma, T., Atsumi, T., Kaneko, Y., Kameda, H., Kuwana, M., Tanaka, Y., Nakagawa, S., Nakajima, A., Hiramatsu, Y., Fujita, D., Miyamae, T. & Murashima, A., 2024 11月 1, In: Modern rheumatology. 34, 6, p. 1170-1177 8 p.

研究成果: Article › 査読

Open Access

Disease-specific autoantibody production in the lungs and salivary glands of anti-synthetase syndrome

Takeshita, M., Suzuki, K., Nakazawa, M., Kamata, H., Ishii, M., Oyamada, Y., Oshima, H., Usuda, S., Tsunoda, K. & Takeuchi, T., 2024, In: Frontiers in Immunology. 15, 1265792.

研究成果: Article › 査読

Open Access

Effects of interleukin-6 signal inhibition on Treg subpopulations and association of Tregs with clinical outcomes in rheumatoid arthritis

Yoshida, H., Magi, M., Tamai, H., Kikuchi, J., Yoshimoto, K., Otomo, K., Matsumoto, Y., Noguchi-Sasaki, M., Takeuchi, T. & Kaneko, Y., 2024 9月 1, In: Rheumatology (United Kingdom). 63, 9, p. 2515-2524 10 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Efficient detection of somatic UBA1 variants and clinical scoring system predicting patients with variants in VEXAS syndrome

Maeda, A., Tsuchida, N., Uchiyama, Y., Horita, N., Kobayashi, S., Kishimoto, M., Kobayashi, D., Matsumoto, H., Asano, T., Migita, K., Kato, A., Mori, I., Morita, H., Matsubara, A., Marumo, Y., Ito, Y., Machiyama, T., Shirai, T., Ishii, T. & Kishibe, M. & 72 others, Yoshida, Y., Hirata, S., Akao, S., Higuchi, A., Rokutanda, R., Nagahata, K., Takahashi, H., Katsuo, K., Ohtani, T., Fujiwara, H., Nagano, H., Hosokawa, T., Ito, T., Haji, Y., Yamaguchi, H., Hagino, N., Shimizu, T., Koga, T., Kawakami, A., Kageyama, G., Kobayashi, H., Aoki, A., Mizokami, A., Takeuchi, Y., Motohashi, R., Hagiyama, H., Itagane, M., Teruya, H., Kato, T., Miyoshi, Y., Kise, T., Yokogawa, N., Ishida, T., Umeda, N., Isogai, S., Naniwa, T., Yamabe, T., Uchino, K., Kanasugi, J., Takami, A., Kondo, Y., Furuhashi, K., Saito, K., Ohno, S., Kishimoto, D., Yamamoto, M., Fujita, Y., Fujieda, Y., Araki, S., Tsushima, H., Misawa, K., Katagiri, A., Kobayashi, T., Hashimoto, K., Sone, T., Hidaka, Y., Ida, H., Nishikomori, R., Doi, H., Fujimaki, K., Akasaka, K., Amano, M., Matsushima, H., Kashino, K., Ohnishi, H., Miwa, Y., Takahashi, N., Takase-Minegishi, K., Yoshimi, R., Kirino, Y., Nakajima, H. & Matsumoto, N., 2024 8月 1, In: Rheumatology (United Kingdom). 63, 8, p. 2056-2064 9 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Ensemble detection of hand joint ankylosis and subluxation in radiographic images using deep neural networks

Izumi, K., Suzuki, K., Hashimoto, M., Jinzaki, M., Ko, S., Takeuchi, T. & Kaneko, Y., 2024 12月, In: Scientific reports. 14, 1, 7696.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Expansion of granulocyte-macrophage colony-stimulating factor producing CD4+ T cells in an animal model with enhanced interleukin-1 signal

Ishigaki, S., Yoshimoto, K., Akiyama, M., Matsumoto, K., Suzuki, K., Yamanoi, K., Iwakura, Y., Takeuchi, T. & Kaneko, Y., 2024, (Accepted/In press) In: Immunological Medicine.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Flares in IIMs and the timeline following COVID-19 vaccination: a combined analysis of the COVAD-1 and -2 surveys

COVAD Study Group, 2024 1月 1, In: Rheumatology. 63, 1, p. 127-139 13 p.

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Gender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset

COVAD Study Group, 2024 7月 1, In: Modern rheumatology. 34, 4, p. 756-766 11 p.

研究成果: Article › 査読

Global disparities in the treatment of idiopathic inflammatory myopathies: results from an international online survey study

COVAD Study Group, 2024 3月 1, In: Rheumatology (United Kingdom). 63, 3, p. 657-664 8 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Healthcare resource utilisation and economic burden of patients with adequate and inadequate responses to biological and targeted synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis in Japan

Ikeda, K., Kaneko, Y., Tsujita, Y., Kawaguchi, I., Patel, J., Yamazaki, T., Fang, S. & Kawahito, Y., 2024 9月 1, In: Modern rheumatology. 34, 5, p. 910-917 8 p.

研究成果: Article › 査読

Illustrations of rheumatoid arthritis symptoms to promote communication between patients and physicians

Kaneko, Y., Hasegawa, M., Ikeda, K., Nakano, K., Kadono, Y., Tanaka, Y. & Takeuchi, T., 2024 1月 1, In: Modern rheumatology. 34, 1, p. 87-91 5 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Interleukin-17A is a potential therapeutic target predicted by proteomics for systemic sclerosis patients at high risk of pulmonary arterial hypertension

Ono, Y., Mogami, A., Saito, R., Seki, N., Ishigaki, S., Takei, H., Yoshimoto, K., Chiba, K., Takeuchi, T. & Kaneko, Y., 2024 12月, In: Scientific reports. 14, 1, 29484.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Leucine-rich α2-glycoprotein as a useful biomarker for evaluating disease activity in rheumatoid arthritis

Fujimoto, M., Hosono, Y., Serada, S., Suzuki, Y., Ohkawara, T., Murata, O., Quick, A., Suzuki, K., Kaneko, Y., Takeuchi, T. & Naka, T., 2024 9月 1, In: Modern rheumatology. 34, 5, p. 1072-1075 4 p.

研究成果: Article › 査読

Longitudinal analysis at pre- and post-flare of T peripheral helper and T follicular helper subsets in patients with systemic lupus erythematosus

Seki, N., Tsujimoto, H., Tanemura, S., Kikuchi, J., Saito, S., Sugahara, K., Yoshimoto, K., Akiyama, M., Takeuchi, T., Chiba, K. & Kaneko, Y., 2024 10月, In: Immunology Letters. 269, 106905.

研究成果: Article › 査読

Open Access

Long-read sequencing for 29 immune cell subsets reveals disease-linked isoforms

Inamo, J., Suzuki, A., Ueda, M. T., Yamaguchi, K., Nishida, H., Suzuki, K., Kaneko, Y., Takeuchi, T., Hatano, H., Ishigaki, K., Ishihama, Y., Yamamoto, K. & Kochi, Y., 2024 12月, In: Nature communications. 15, 1, 4285.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis

Huynh, N. C. N., Ling, R., Komagamine, M., Shi, T., Tsukasaki, M., Matsuda, K., Okamoto, K., Asano, T., Muro, R., Pluemsakunthai, W., Kollias, G., Kaneko, Y., Takeuchi, T., Tanaka, S., Komatsu, N. & Takayanagi, H., 2024 12月, In: Inflammation and Regeneration. 44, 1, 36.

研究成果: Article › 査読

3 被引用数 (Scopus)

Performance of the 2022 ACR/EULAR Classification Criteria in Comparison With the European Medicines Agency Algorithm in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Imai, Y., Ota, Y., Matsumoto, K., Akiyama, M., Suzuki, K. & Kaneko, Y., 2024 11月 1, In: Journal of Rheumatology. 51, 11, p. 1102-1110 9 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Physician approval for pregnancy in patients with systemic lupus erythematosus showing only serological activity: A vignette survey study

Isojima, S., Yajima, N., Yanai, R., Miura, Y., Fukuma, S., Kaneko, K., Fujio, K., Oku, K., Matsushita, M., Miyamae, T., Wada, T., Tanaka, Y., Kaneko, Y., Nakajima, A. & Murashima, A., 2024 5月 1, In: Modern rheumatology. 34, 3, p. 509-514 6 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Re-emphasising the importance of catheter-based angiography to differentiate polyarteritis nodosa from cutaneous arteritis:Two case reports

Suzuki, K., Akiyama, M., Kondo, Y., Saito, S., Kikuchi, J., Hanaoka, H. & Kaneko, Y., 2024 1月 1, In: Modern Rheumatology Case Reports. 8, 1, p. 133-136 4 p.

研究成果: Article › 査読

Open Access

Risk of disease flares after SARS-CoV-2 mRNA vaccination in patients with systemic lupus erythematosus

Kikuchi, J., Kondo, Y., Kojima, S., Kasai, S., Sakai, Y., Takeshita, M., Hiramoto, K., Saito, S., Fukui, H., Hanaoka, H., Suzuki, K. & Kaneko, Y., 2024, In: Immunological Medicine. 47, 2, p. 76-84 9 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study

the Asia-Pacific Lupus Collaboration, 2024 7月 15, In: Annals of the rheumatic diseases. 83, 8, p. 998-1005 8 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

内科学(リウマチ・膠原病)

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