年別の研究成果
年別の研究成果
- 1 - 50 / 81 件
検索結果
-
2022
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Schmitt, M., Ceteci, F., Gupta, J., Pesic, M., Böttger, T. W., Nicolas, A. M., Kennel, K. B., Engel, E., Schewe, M., Callak Kirisözü, A., Petrocelli, V., Dabiri, Y., Varga, J., Ramakrishnan, M., Karimova, M., Ablasser, A., Sato, T., Arkan, M. C., de Sauvage, F. J. & Greten, F. R., 2022 12月 8, In: Nature. 612, 7939, p. 347-353 7 p.研究成果: Article › 査読
15 被引用数 (Scopus) -
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium
Oda, M., Hatano, Y. & Sato, T., 2022 10月, In: Current Opinion in Genetics and Development. 76, 101977.研究成果: Review article › 査読
2 被引用数 (Scopus) -
In Vivo Intestinal Research Using Organoid Transplantation
Sugimoto, S., Kobayashi, E., Kanai, T. & Sato, T., 2022, In: Keio Journal of Medicine. 71, 4, p. 73-81 9 p.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids
Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2022 12月, In: Micromachines. 13, 12, 2082.研究成果: Article › 査読
Open Access -
Organoid Medicine for Inflammatory Bowel Disease
Wakisaka, Y., Sugimoto, S. & Sato, T., 2022 2月, In: Stem Cells. 40, 2, p. 123-132 10 p.研究成果: Review article › 査読
6 被引用数 (Scopus) -
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer
Toshimitsu, K., Takano, A., Fujii, M., Togasaki, K., Matano, M., Takahashi, S., Kanai, T. & Sato, T., 2022 6月, In: Nature Chemical Biology. 18, 6, p. 605-614 10 p.研究成果: Article › 査読
15 被引用数 (Scopus) -
Organoid vs In Vivo Mouse Model: Which is Better Research Tool to Understand the Biologic Mechanisms of Intestinal Epithelium?
Sugimoto, S. & Sato, T., 2022 1月, In: CMGH. 13, 1, p. 195-197 3 p.研究成果: Comment/debate › 査読
Open Access10 被引用数 (Scopus) -
2021
Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data
Shimozaki, K., Sukawa, Y., Sato, Y., Horie, S., Chida, A., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y. & Kanai, T., 2021 7月, In: Future Oncology. 17, 20, p. 2593-2603 11 p.研究成果: Article › 査読
Open Access8 被引用数 (Scopus) -
An organoid-based organ-repurposing approach to treat short bowel syndrome
Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., Nanki, K., Hakamata, Y., Kanai, T. & Sato, T., 2021 4月 1, In: Nature. 592, 7852, p. 99-104 6 p.研究成果: Article › 査読
71 被引用数 (Scopus) -
COVID-19 reinfection: A rapid systematic review of case reports and case series
Wang, J., Kaperak, C., Sato, T. & Sakuraba, A., 2021 8月 1, In: Journal of Investigative Medicine. 69, 6, p. 1253-1255 3 p.研究成果: Review article › 査読
69 被引用数 (Scopus) -
Demarcated redness associated with increased vascular density/size: A useful marker of flat-type dysplasia in patients with ulcerative colitis
Ikebata, A., Shimoda, M., Okabayashi, K., Uraoka, T., Maehata, T., Sugimoto, S., Mutaguchi, M., Naganuma, M., Kameyama, K., Yahagi, N., Kanai, T., Kitagawa, Y., Kanai, Y. & Iwao, Y., 2021 4月 1, In: Endoscopy International Open. 9, 4, p. E552-E561研究成果: Article › 査読
Open Access -
Phenotypic screening system using three-dimensional (3D) culture models for natural product screening
Suenaga, H., Kagaya, N., Kawada, M., Tatsuda, D., Sato, T. & Shin-ya, K., 2021 10月, In: Journal of Antibiotics. 74, 10, p. 660-666 7 p.研究成果: Review article › 査読
1 被引用数 (Scopus) -
Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases
Fujii, M. & Sato, T., 2021 2月, In: Nature Materials. 20, 2, p. 156-169 14 p.研究成果: Review article › 査読
Open Access81 被引用数 (Scopus) -
Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer
Togasaki, K., Sugimoto, S., Ohta, Y., Nanki, K., Matano, M., Takahashi, S., Fujii, M., Kanai, T. & Sato, T., 2021 2月, In: Gastroenterology. 160, 3, p. 823-830 8 p.研究成果: Short survey › 査読
Open Access32 被引用数 (Scopus) -
2020
A microfluidic organoid trapping device to form tube-like intestinal organoids
Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 871-872 2 p. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).研究成果: Conference contribution
-
Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine
Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 12月 1, In: Scientific reports. 10, 1, 8308.研究成果: Article › 査読
Open Access11 被引用数 (Scopus) -
Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma
Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 2月, In: Gastroenterology. 158, 3, p. 638-651.e8研究成果: Article › 査読
44 被引用数 (Scopus) -
Linking human intestinal scaffolds and organoids to combat intestinal failure
Fujii, M., Sugimoto, S. & Sato, T., 2020 10月 1, In: Nature medicine. 26, 10, p. 1517-1518 2 p.研究成果: Comment/debate › 査読
3 被引用数 (Scopus) -
Multiple immune-related adverse events and anti-tumor efficacy: Real-world data on various solid tumors
Shimozaki, K., Sukawa, Y., Beppu, N., Kurihara, I., Suzuki, S., Mizuno, R., Funakoshi, T., Ikemura, S., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y., Takaishi, H. & Kanai, T., 2020, In: Cancer Management and Research. 12, p. 4585-4593 9 p.研究成果: Article › 査読
Open Access29 被引用数 (Scopus) -
Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics
Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, In: International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.研究成果: Article › 査読
7 被引用数 (Scopus) -
Organoid derivation and orthotopic xenotransplantation for studying human intestinal stem cell dynamics
Sugimoto, S., Fujii, M. & Sato, T., 2020, Methods in Molecular Biology. Humana Press Inc., p. 303-320 18 p. (Methods in Molecular Biology; vol. 2171).研究成果: Chapter
6 被引用数 (Scopus) -
Racial disparities in COVID-19 deaths reveal harsh truths about structural inequality in America
Anyane-Yeboa, A., Sato, T. & Sakuraba, A., 2020 10月 1, In: Journal of Internal Medicine. 288, 4, p. 479-480 2 p.研究成果: Letter › 査読
Open Access55 被引用数 (Scopus) -
Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages
Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 8月 1, In: Nature Cell Biology. 22, 8, p. 919-926 8 p.研究成果: Article › 査読
14 被引用数 (Scopus) -
2019
Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia
Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5月 16, In: Oncogene. 38, 20, p. 3962-3969 8 p.研究成果: Article › 査読
12 被引用数 (Scopus) -
Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients
Mutaguchi, M., Naganuma, M., Sugimoto, S., Fukuda, T., Nanki, K., Mizuno, S., Hosoe, N., Shimoda, M., Ogata, H., Iwao, Y. & Kanai, T., 2019 9月, In: Digestive and Liver Disease. 51, 9, p. 1257-1264 8 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia
Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 11月 1, In: Digestive Endoscopy. 31, 6, p. 706-711 6 p.研究成果: Article › 査読
6 被引用数 (Scopus) -
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine
Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M., & 5 others, 2019 10月 1, In: Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids
Fujii, M., Clevers, H. & Sato, T., 2019 2月, In: Gastroenterology. 156, 3, p. 562-576 15 p.研究成果: Review article › 査読
Open Access82 被引用数 (Scopus) -
2018
Advancing Intestinal Organoid Technology Toward Regenerative Medicine
Nakamura, T. & Sato, T., 2018, In: CMGH. 5, 1, p. 51-60 10 p.研究成果: Review article › 査読
82 被引用数 (Scopus) -
Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: An evidence-based review of therapies
Togasaki, K., Sukawa, Y., Kanai, T. & Takaishi, H., 2018, In: OncoTargets and Therapy. 11, p. 8239-8250 12 p.研究成果: Review article › 査読
Open Access29 被引用数 (Scopus) -
Erratum to: Efficient genetic engineering of human intestinal organoids using electroporation (Nature Protocols, (2015), 10, 10, (1474-1485), 10.1038/nprot.2015.088)
Fujii, M., Matano, M., Nanki, K. & Sato, T., 2018 1月 1, (Accepted/In press) In: Nature Protocols.研究成果: Article › 査読
2 被引用数 (Scopus) -
Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease
Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10月, In: PloS one. 13, 10, e0204632.研究成果: Article › 査読
15 被引用数 (Scopus) -
Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis
Kasuga, A., Hamamoto, Y., Takeuchi, A., Okano, N., Togasaki, K., Aoki, Y., Suzuki, T., Kawasaki, K., Hirata, K., Sukawa, Y., Kanai, T. & Takaishi, H., 2018 10月 1, In: Investigational new drugs. 36, 5, p. 939-948 10 p.研究成果: Review article › 査読
6 被引用数 (Scopus) -
Reconstruction of the Human Colon Epithelium In Vivo
Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2月 1, In: Cell stem cell. 22, 2, p. 171-176.e5研究成果: Article › 査読
124 被引用数 (Scopus) -
2017
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., & 19 others, 2017 5月 1, In: Nature Cell Biology. 19, 5, p. 530-541 12 p.研究成果: Article › 査読
137 被引用数 (Scopus) -
Defining the role of Lgr5+ stem cells in colorectal cancer: From basic research to clinical applications
Fujii, M. & Sato, T., 2017 7月 18, In: Genome Medicine. 9, 1, 66.研究成果: Comment/debate › 査読
7 被引用数 (Scopus) -
Endoscopic morphologic features of ulcerative colitis–associated dysplasia classified according to the SCENIC consensus statement
Sugimoto, S., Naganuma, M., Iwao, Y., Matsuoka, K., Shimoda, M., Mikami, S., Mizuno, S., Nakazato, Y., Nanki, K., Inoue, N., Ogata, H. & Kanai, T., 2017 3月 1, In: Gastrointestinal Endoscopy. 85, 3, p. 639-646.e2研究成果: Article › 査読
33 被引用数 (Scopus) -
Establishment of 3D intestinal organoid cultures from intestinal stem cells
Sugimoto, S. & Sato, T., 2017, Methods in Molecular Biology. Humana Press Inc., p. 97-105 9 p. (Methods in Molecular Biology; vol. 1612).研究成果: Chapter
42 被引用数 (Scopus) -
Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice
Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 8月 15, In: Cell Reports. 20, 7, p. 1513-1524 12 p.研究成果: Article › 査読
Open Access75 被引用数 (Scopus) -
The risk factor of clinical relapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as maintenance therapy: A report from the IBD registry
Fukuda, T., Naganuma, M., Sugimoto, S., Nanki, K., Mizuno, S., Mutaguchi, M., Nakazato, Y., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 11月, In: PloS one. 12, 11, e0187737.研究成果: Article › 査読
22 被引用数 (Scopus) -
Visualization and targeting of LGR5 + human colon cancer stem cells
Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 5月 11, In: Nature. 545, 7653, p. 187-192 6 p.研究成果: Article › 査読
462 被引用数 (Scopus) -
2016
Discrepancy in the classification of water immersion from water exchange colonoscopy
Sugimoto, S. & Mizukami, T., 2016 3月 1, In: Gastrointestinal Endoscopy. 83, 3, p. 676-677 2 p.研究成果: Letter › 査読
1 被引用数 (Scopus) -
Indole compounds may be promising medicines for ulcerative colitis
Sugimoto, S., Naganuma, M. & Kanai, T., 2016 9月 1, In: Journal of gastroenterology. 51, 9, p. 853-861 9 p.研究成果: Review article › 査読
82 被引用数 (Scopus) -
Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response
Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 5月 4, In: Scientific reports. 6, 25311.研究成果: Article › 査読
Open Access24 被引用数 (Scopus) -
Recent trends and future directions for the medical treatment of ulcerative colitis
Naganuma, M., Mizuno, S., Nanki, K., Sugimoto, S. & Kanai, T., 2016 12月 1, In: Clinical journal of gastroenterology. 9, 6, p. 329-336 8 p.研究成果: Review article › 査読
26 被引用数 (Scopus) -
Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab
Saigusa, K., Matsuoka, K., Sugimoto, S., Arai, M., Kiyohara, H., Takeshita, K., Mizuno, S., Mori, K., Nanki, K., Takeshita, T., Nakazato, Y., Yajima, T., Naganuma, M., Hisamatsu, T., Ogata, H., Iwao, Y. & Kanai, T., 2016 9月 1, In: Digestive Endoscopy. 28, 6, p. 665-670 6 p.研究成果: Article › 査読
25 被引用数 (Scopus) -
2015
An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium
Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 2月 1, In: Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.研究成果: Article › 査読
26 被引用数 (Scopus) -
Efficient genetic engineering of human intestinal organoids using electroporation
Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 10月 29, In: Nature Protocols. 10, 10, p. 1474-1485 12 p.研究成果: Article › 査読
205 被引用数 (Scopus) -
Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis
Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 6月 1, In: Cancer Prevention Research. 8, 6, p. 492-501 10 p.研究成果: Article › 査読
13 被引用数 (Scopus) -
Mini-Gut Organoids: Reconstitution of the Stem Cell Niche
Date, S. & Sato, T., 2015 11月 13, In: Annual Review of Cell and Developmental Biology. 31, p. 269-289 21 p.研究成果: Article › 査読
140 被引用数 (Scopus)