TY - JOUR
T1 - β-Carboline-Carbohydrate hybrids
T2 - Molecular design, chemical synthesis and evaluation of novel DNA photocleavers
AU - Toshima, Kazunobu
AU - Okuno, Yukiko
AU - Nakajima, Yoko
AU - Matsumura, Shuichi
N1 - Funding Information:
We gratefully acknowledge a Grant-in-Aid for General Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan, and the Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects.
PY - 2002/2/25
Y1 - 2002/2/25
N2 - β-Carboline present in β-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and β-carboline-carbohydrate hybrid system was effective for DNA cleavage.
AB - β-Carboline present in β-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and β-carboline-carbohydrate hybrid system was effective for DNA cleavage.
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U2 - 10.1016/S0960-894X(01)00828-9
DO - 10.1016/S0960-894X(01)00828-9
M3 - Article
C2 - 11844697
AN - SCOPUS:0037170070
SN - 0960-894X
VL - 12
SP - 671
EP - 673
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 4
ER -
