機能性ディスペプシアの十二指腸が果たす役割

Although functional dyspepsia is highly prevalent and is often seen in outpatient clinic, the pathophysiology of the disease remains unknown due to the presence of multiple factors. Traditionally, research has focused on the gastric mucosa and gastric function because of the presence of symptoms such as “postprandial fullness” and “epigastralgia”. However, recent research into the core pathophysiology of functional dyspepsia has focused on the duodenum. The major pathophysiology observed in functional dyspepsia is that low-grade inflammation associated with eosinophil and mast cell infiltration causes mucosal barrier dysfunction, and various foreign substances stimulate the afferent nerves and gastrointestinal hormones, leading to impaired gastric adaptive relaxation and gastric motility.