@article{65b77132fe5147c79b935efc225a81e0,
title = "2-Methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling",
abstract = "A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. Compound 1 inhibited the TCF/β-catenin (TOP) transcriptional activity (IC50 2.9 μM), while it decreased the transcriptional activity of FOP (mutated TCF-binding site)-transfected cells at >5 μM.",
keywords = "Impatiens balsamina, Luciferase, Naphthoquinone, Wnt",
author = "Naomi Mori and Kazufumi Toume and Arai, {Midori A.} and Takashi Koyano and Thaworn Kowithayakorn and Masami Ishibashi",
note = "Funding Information: Acknowledgments We are grateful to Prof. J. Nathans (John Hopkins Medical School) for the STF/293 cells and Prof. R. T. Moon (University of Washington) for the SuperTOP-Flash and SuperFOP-Flash plasmids. This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), the Japan Science and Technology Agency (JST), and the Chiba Foundation for Health Promotion and Disease Prevention.",
year = "2011",
month = jan,
doi = "10.1007/s11418-010-0471-0",
language = "English",
volume = "65",
pages = "234--236",
journal = "Journal of Natural Medicines",
issn = "1340-3443",
publisher = "Springer Japan",
number = "1",
}