TY - JOUR
T1 - A case of Fournier's gangrene caused by small intestinal perforation during bevacizumab combination chemotherapy
AU - Ishida, Takashi
AU - Shinozaki, Hiroharu
AU - Ozawa, Hiroki
AU - Kobayashi, Toshimichi
AU - Kato, Subaru
AU - Wakabayashi, Taiga
AU - Matsumoto, Kenji
AU - Sasakura, Yuuichi
AU - Shimizu, Tetsuichiro
AU - Terauchi, Toshiaki
AU - Kimata, Masaru
AU - Furukawa, Junji
AU - Kobayashi, Kenji
AU - Ogata, Yoshiro
PY - 2016/7
Y1 - 2016/7
N2 - A 51-year-old man underwent abdominoperineal resection for advanced rectal cancer at a hospital. He attended our outpatient clinic 58 months later with pain in the external genitalia, and was diagnosed with local pelvic recurrence and metastasis to the para-aortic lymph node and both adrenal glands. He received a total of 30 Gy of radiation for analgesia; subsequently, chemotherapy (mFOLFOX6 plus bevacizumab) was initiated. However, extreme left buttock and left femoral pain developed after the 6 courses of chemotherapy. Abdominal CT revealed Fournier's gangrene caused by small intestinal perforation. Emergency drainage under spinal anesthesia was immediately performed. Two additional drainage procedures were required thereafter and an ileostomy was constructed. The patient was discharged 100 days after the initial drainage. This is an extremely rare example of a bevacizumab-related small intestinal perforation that developed into Fournier's gangrene.
AB - A 51-year-old man underwent abdominoperineal resection for advanced rectal cancer at a hospital. He attended our outpatient clinic 58 months later with pain in the external genitalia, and was diagnosed with local pelvic recurrence and metastasis to the para-aortic lymph node and both adrenal glands. He received a total of 30 Gy of radiation for analgesia; subsequently, chemotherapy (mFOLFOX6 plus bevacizumab) was initiated. However, extreme left buttock and left femoral pain developed after the 6 courses of chemotherapy. Abdominal CT revealed Fournier's gangrene caused by small intestinal perforation. Emergency drainage under spinal anesthesia was immediately performed. Two additional drainage procedures were required thereafter and an ileostomy was constructed. The patient was discharged 100 days after the initial drainage. This is an extremely rare example of a bevacizumab-related small intestinal perforation that developed into Fournier's gangrene.
KW - Bevacizumab
KW - Fournier's gangrene
KW - Rectal cancer
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M3 - Article
C2 - 27431640
AN - SCOPUS:84991510924
SN - 0385-0684
VL - 43
SP - 909
EP - 911
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 7
ER -
