HIV-associated salivary gland disease (HSD) is one of the initial symptoms of HIV infection. HSD occurs in about 5%∼10% HIV patients. Usually, HSD shows multilocular soft cystic lesions in parotid glands; however, it does not show bilateral parotid abscesses. We report the case of a 32-year-old man with HIV infection that initially presented as bilateral parotid abscesses. He came to our hospital with a 1-week history of bilateral parotid swelling. He did not have a history of HIV infection, diabetes mellitus, or tuberculosis infection. We performed incision and drainage, bacterial culture, and serological examination, which showed HIV infection. This is a rare case of HSD starting as bilateral parotid abscesses. Because cystic enlargement of the bilateral parotid glands is an unusual condition in the HIV-negative population, HIV testing should be recommended in such cases.
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