We report a case of jejunal serosal patch for repair of duodenal wall defect after local excision of duodenal leiomyoma. A 30-year-old man seen for a bloody stool was diagnosed with bleeding from a submucosal tumor in the contralateral of papilla by gastrointestinal endoscopy. Emergency surgery was conducted because blood pressure was instable during examination. We locally excised the tumor with sufficient margin. The defect was more than a semicircle of the duodenal wall, so we repaired the defect using a jejunal serosal patch. The postoperative course was uneventful. The tumor was diagnosed immunohistologically as leiomyoma. In double-contrast radiography of the duodenal second portion after surgery, no stenosis or deformation was observed. In gastrointestinal endoscopy, we confirmed new mucosal epithelium in the area of the jejunal patch. When the defect of duodenal wall after local excision of duodenal leiomyoma is more than a semicircle, the jejunal serosal patch is recommended.
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