A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

Masahiro Kubo; Hiroki Yotsuda; Taro Kosaka; Nobuhiko Nakano

doi:10.1109/ISPACS.2015.7432786

A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

Masahiro Kubo, Hiroki Yotsuda, Taro Kosaka, Nobuhiko Nakano

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.

本文言語	English
ホスト出版物のタイトル	2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015
出版社	Institute of Electrical and Electronics Engineers Inc.
ページ	307-311
ページ数	5
ISBN（印刷版）	9781467364997
DOI	https://doi.org/10.1109/ISPACS.2015.7432786
出版ステータス	Published - 2016 3月 11
イベント	International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015 - Nusa Dua, Bali, Indonesia 継続期間: 2015 11月 9 → 2015 11月 12

Other

Other	International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015
国/地域	Indonesia
City	Nusa Dua, Bali
Period	15/11/9 → 15/11/12

ASJC Scopus subject areas

人工知能
コンピュータネットワークおよび通信
信号処理

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10.1109/ISPACS.2015.7432786

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引用スタイル

Kubo, M., Yotsuda, H., Kosaka, T., & Nakano, N. (2016). A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. In 2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015 (pp. 307-311). 記事 7432786 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISPACS.2015.7432786

A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. / Kubo, Masahiro; Yotsuda, Hiroki; Kosaka, Taro その他.
2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015. Institute of Electrical and Electronics Engineers Inc., 2016. p. 307-311 7432786.

研究成果: Conference contribution

Kubo, M, Yotsuda, H, Kosaka, T & Nakano, N 2016, A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. in 2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015., 7432786, Institute of Electrical and Electronics Engineers Inc., pp. 307-311, International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015, Nusa Dua, Bali, Indonesia, 15/11/9. https://doi.org/10.1109/ISPACS.2015.7432786

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AB - Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.

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A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

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