@article{f7e45c27490d47f59ff0c1fd9df2d28a,
title = "A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis",
abstract = "We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.",
keywords = "Cdc2, Centrosome, Chromosome 6q, Midbody, Mitotic spindle, Nocodazole",
author = "Yasuyuki Nishiyama and Toru Hirota and Tetsuro Morisaki and Toshihiro Hara and Tomotoshi Marumoto and Iida, {Shin Ichi} and Keishi Makino and Hideyuki Yamamoto and Takehisa Hiraoka and Nobuo Kitamura and Hideyuki Saya",
note = "Funding Information: We thank Drs. Q. Hu, and H. Maruta for providing the pCGN, and pGEX-2TH plasmids, respectively; Drs. H. Koga, N. Hanada, T. Tada, H. Nakamura and N. Mugita for valuable discussion; Dr. J. Moon for editing the manuscript; and T. Arino and K. Uriuda for secretarial assistance. This work was supported by Research Grant of the Princess Takamatsu Cancer Research Fund (#97-22906) and a grant for Cancer Research from the Ministry of Education, Science and Culture of Japan (H.S.).",
year = "1999",
month = oct,
day = "8",
doi = "10.1016/S0014-5793(99)01224-7",
language = "English",
volume = "459",
pages = "159--165",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",
}