A kaurene-type novel phytotoxic substance in Wedelia chinensis

Krishna Rany Das; Arihiro Iwasaki; Kiyotake Suenaga; Hisashi Kato-Noguchi

doi:10.1016/j.tetlet.2020.151600

A kaurene-type novel phytotoxic substance in Wedelia chinensis

Krishna Rany Das, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

化学科

研究成果: Article › 査読

3 被引用数 (Scopus)

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Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

本文言語	English
論文番号	151600
ジャーナル	Tetrahedron Letters
巻	61
号	11
DOI	https://doi.org/10.1016/j.tetlet.2020.151600
出版ステータス	Published - 2020 3月 12

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/j.tetlet.2020.151600

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title = "A kaurene-type novel phytotoxic substance in Wedelia chinensis",

abstract = "Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.",

keywords = "Bioactive compound, Growth inhibitor, Kaurene, Phytotoxicity, Wedelia chinensis",

author = "{Rany Das}, Krishna and Arihiro Iwasaki and Kiyotake Suenaga and Hisashi Kato-Noguchi",

note = "Funding Information: This work was partly supported by Asia Joint Research Promotion Fund of Kagawa University Research Promotion Program 2019. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

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AU - Rany Das, Krishna

AU - Iwasaki, Arihiro

AU - Suenaga, Kiyotake

AU - Kato-Noguchi, Hisashi

PY - 2020/3/12

Y1 - 2020/3/12

N2 - Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

AB - Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

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A kaurene-type novel phytotoxic substance in Wedelia chinensis

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