A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding

Osamu Goto, Mitsuhiro Fujishiro, Ichiro Oda, Naomi Kakushima, Yorimasa Yamamoto, Yosuke Tsuji, Ken Ohata, Takashi Fujiwara, Junko Fujiwara, Naoki Ishii, Chizu Yokoi, Shinichi Miyamoto, Toshiyuki Itoh, Shinji Morishita, Takuji Gotoda, Kazuhiko Koike

研究成果: Article査読

74 被引用数 (Scopus)


Background and Aims: Bleeding is a major complication after gastric endoscopic submucosal dissection (ESD). An evidence-based strategy for postoperative care related to delayed bleeding is required. We conducted a multicenter survey to assess the current status of management after gastric ESD. Methods: A total of 1,814 gastric epithelial neoplasms in 2009 at ten tertiary referral centers were enrolled. The current status of the management after gastric ESD (use of an antisecretory drug, food intake, and second-look endoscopy) at participating hospitals was assessed. Furthermore, the rate of post-ESD bleeding and the differences in each parameter were retrospectively analyzed. Results: Postoperative bleeding occurred in 100 cases (5.5%), which included 62 cases of bleeding within 24 h after ESD. In all of the hospitals, proton pump inhibitors (PPIs) were used. The median administration period was 56 days (range 14-60 days). Food intake was resumed from postoperative day (POD) 1 in 4 hospitals and from POD 2 in 6 hospitals. Second-look endoscopy was performed for almost all cases, fewer cases, and rarely or none in 6, 2, and 2 hospitals, respectively. The day of second-look endoscopy varied among hospitals. There was no statistical relationship between the postoperative bleeding rate and the differences in these three parameters. Conclusions: Post-ESD management (duration of PPI use, resumption of food intake, and performance of second-look endoscopy) varied among the medical centers; thus, randomized controlled trials are required for an optimal strategy after gastric ESD.

ジャーナルDigestive Diseases and Sciences
出版ステータスPublished - 2012 2月

ASJC Scopus subject areas

  • 生理学
  • 消化器病学


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