A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure

Vanguard Multicenter Study of International Living Donor Liver Transplantation (iLDLT) group

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Liver transplantation is often the only lifesaving option for acute liver failure (ALF); however, the predictors of short-term mortality (death within one year) after living donor liver transplantation (LDLT) for ALF have yet to be defined. We retrospectively collected patients ≥18 years old who underwent LDLT for ALF between 2010 and 2020 at 35 centers in Asia. Univariate and multivariate logistic regression analyses were conducted to identify the clinical variables related to short-term mortality and establish a novel scoring system. The Kaplan-Meier method was performed to explore the association between the score and overall survival. Of the 339 recipients, 46 (13.6%) died within 1 year after LDLT. Multivariate analyses revealed 4 independent risk factors for death: use of vasopressors or mechanical ventilation, the higher model for end-stage liver disease score, and a lower graft-to-recipient weight ratio. The internally validated c-statistic of the short-term mortality after transplant (SMT) score derived from these 4 variables was 0.80 (95% confidence interval: 0.74-0.87). The SMT score successfully stratified recipients into low-, intermediate-, and high-risk groups with 1-year overall survival rates of 96%, 80%, and 50%, respectively. In conclusion, our novel SMT score based on 4 predictors will guide ALF recipient and living donor selection.

本文言語English
ページ(範囲)1857-1867
ページ数11
ジャーナルAmerican Journal of Transplantation
24
10
DOI
出版ステータスPublished - 2024 10月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 移植
  • 薬理学(医学)

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