A randomized, controlled trial of weekly administration of lymphoblastoid interferon in patients with chronic hepatitis C

Tatehiro Kagawa, Toshio Morizane, Hidetsugu Saito, Shingo Miyaguchi, Satoshi Tsunematsu, Shinichirou Tada, Ferdinand M. Guevara, Naoki Kumagai, Kanji Tsuchimoto, Tetsu Watanabe, Masaharu Tsuchiya

研究成果: Article査読

27 被引用数 (Scopus)

抄録

To evaluate the efficacy of a treatment of weekly interferon administration in patients with chronic hepatitis C, 36 patients were randomly assigned to two groups. In one group lymphoblastoid interferon was given at a dose of 6 million units, intramuscularly, once per week for 24 weeks, and no treatment was given to the other. Serum alanine aminotransferase levels in the treated group were significantly lower during therapy than in the control group, although there was no significant difference between these two groups before therapy. The normalization of serum alanine aminotransferase levels at the end of therapy was observed in 50% of the treated group, and in 11.1% of the control group. This difference was statistically significant (p < 0.03). Response to interferon was better in patients with chronic persistent hepatitis or with chronic active hepatitis than in patients with chronic active hepatitis with cirrhosis. Relapse after the end of therapy was observed in 83.3% of the responders. These results indicate that the weekly administration of 6 million units of lymphoblastoid interferon is effective in decreasing serum alanine aminotransferase levels in patients with type C chronic persistent hepatitis or chronic active hepatitis.

本文言語English
ページ(範囲)91-96
ページ数6
ジャーナルJournal of Hepatology
17
1
DOI
出版ステータスPublished - 1993
外部発表はい

ASJC Scopus subject areas

  • 肝臓学

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