A receptor-independent effect of estrone sulfate on the hERG channel

Shoko Kakusaka, Mahoko Asayama, Asami Kaihara, Tetsuo Sasano, Takeshi Suzuki, Junko Kurokawa, Tetsushi Furukawa

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17β-estradiol, we investigated receptor-independent effects of estrone, estrone 3-sulfate, and estriol on hERG currents in patch-clamped estrogen-negative HEK293 cells. Only estrone 3-sulfate partially suppressed hERG currents in a receptor-independent manner by modifying the gating. The concentration-dependence of estrone 3-sulfate revealed that physiological levels of circulating estrone 3-sulfate can modulate hERG currents to the maximal extent in both women and men at any age.

本文言語English
ページ(範囲)152-156
ページ数5
ジャーナルJournal of Pharmacological Sciences
109
1
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

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