A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods

Takeshi Sugai, Hideaki Kakeya, Hiromichi Ohta

研究成果: Article査読

38 被引用数 (Scopus)

抄録

(R)-(-)-Mevalonolactone was synthesized starting from a chiral tertiary α-benzyloxy ester, obtained by the lipase-catalyzed enantioselective hydrolysis of the corresponding racemate, in 7 steps and 21.5% overall yield. Intramolecular Friedel-Crafts reaction of an intermediate worked well as the key-step for the new carbon-carbon bond formation.

本文言語English
ページ(範囲)3463-3468
ページ数6
ジャーナルTetrahedron
46
10
DOI
出版ステータスPublished - 1990

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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