@article{105ccf6ed3904c0a91035b79a43ce518,
title = "Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells",
abstract = "Induced pluripotent stem (iPS) cells were recently established from human fibroblasts. In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12 days of embryoid body formation and an additional 10 days of differentiation on Poly-l-ornithine and fibronectin- coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBPα, PPARγ2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells.",
keywords = "Adipocyte, Adipogenesis, Differentiation, Stem cell",
author = "Daisuke Taura and Michio Noguchi and Masakatsu Sone and Kiminori Hosoda and Eisaku Mori and Yohei Okada and Kazutoshi Takahashi and Koichiro Homma and Naofumi Oyamada and Megumi Inuzuka and Takuhiro Sonoyama and Ken Ebihara and Naohisa Tamura and Hiroshi Itoh and Hirofumi Suemori and Norio Nakatsuji and Hideyuki Okano and Shinya Yamanaka and Kazuwa Nakao",
note = "Funding Information: We thank Yoshie Fukuchi for her technical assistance. This work was supported by the project for realization of regenerative medicine of the Ministry of Education, Culture, Sports, Science and Technology, Japan.",
year = "2009",
month = mar,
day = "18",
doi = "10.1016/j.febslet.2009.02.031",
language = "English",
volume = "583",
pages = "1029--1033",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "6",
}