TY - JOUR
T1 - Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae
AU - Isozumi, Rie
AU - Yoshimine, Hiroyuki
AU - Morozumi, Miyuki
AU - Ubukata, Kimiko
AU - Ariyoshi, Koya
PY - 2009/11
Y1 - 2009/11
N2 - A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated.
AB - A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated.
KW - 23S rRNA mutation
KW - Macrolide resistance
KW - Mycoplasma pneumoniae
KW - Pneumonia
UR - http://www.scopus.com/inward/record.url?scp=70350442748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350442748&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1843.2009.01619.x
DO - 10.1111/j.1440-1843.2009.01619.x
M3 - Article
C2 - 19732389
AN - SCOPUS:70350442748
SN - 1323-7799
VL - 14
SP - 1206
EP - 1208
JO - Respirology
JF - Respirology
IS - 8
ER -