TY - JOUR
T1 - An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Root of Astragalus mongholicus
AU - Shimizu, Noriko
AU - Tomoda, Masashi
AU - Kanari, Mieko
AU - Gonda, Ryōko
PY - 1991
Y1 - 1991
N2 - An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus bunge. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 104. It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of u-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of 0-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly a-arabino-β-3,6-galactan type structural units.
AB - An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus bunge. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 104. It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of u-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of 0-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly a-arabino-β-3,6-galactan type structural units.
KW - Astragalus mongholicus
KW - acidic arabinogalactan
KW - immunological activity
KW - polysaccharide structure
KW - reticuloendothelial system
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U2 - 10.1248/cpb.39.2969
DO - 10.1248/cpb.39.2969
M3 - Article
C2 - 1799943
AN - SCOPUS:0026350547
SN - 0009-2363
VL - 39
SP - 2969
EP - 2972
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 11
ER -