TY - GEN
T1 - An air-driven microdevice to tune the anisotropic curvature of cell adhesion plane to pursue the mechanobiology of curved surface
AU - Yamashita, Tadahiro
AU - Matsushita, Ichiro
AU - Sudo, Ryo
N1 - Funding Information:
This work was supported by Grants-in-Aid for Research Activity Startup (18H05963) and Young Scientist (19K20679) from Japan Society for the Promotion of Science. We would like to thank Prof. Takemura and Dr. Imashiro at Keio University for their kind assistance with device fabrication.
Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - A new microdevice controlling the curvature of cell adhering plane is proposed. This microdevice is composed of a cell culture chamber with thin silicone membrane, a microslit and a vacuum chamber. Controlling the air pressure, the curvature of the cell adhering plane can be flexibly tuned in a spatiotemporal way. To prove the concept, vascular smooth muscle is cultured on the curved surface and their response to sudden curvature change is monitored. This microdevice would contribute to pursue fundamental question on how cells recognize the surrounding geometry, which is one of the core interests in the mechanobiology field.
AB - A new microdevice controlling the curvature of cell adhering plane is proposed. This microdevice is composed of a cell culture chamber with thin silicone membrane, a microslit and a vacuum chamber. Controlling the air pressure, the curvature of the cell adhering plane can be flexibly tuned in a spatiotemporal way. To prove the concept, vascular smooth muscle is cultured on the curved surface and their response to sudden curvature change is monitored. This microdevice would contribute to pursue fundamental question on how cells recognize the surrounding geometry, which is one of the core interests in the mechanobiology field.
KW - Cellular orientation
KW - Curvature
KW - Mechanobiology
KW - Smooth muscle cell
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M3 - Conference contribution
AN - SCOPUS:85094952065
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 320
EP - 321
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -