TY - JOUR
T1 - Angiotensin II type 1 receptor blockade prevents decrease in adult stem-like cells in kidney after ureteral obstruction
AU - Marumo, Takeshi
AU - Hishikawa, Keiichi
AU - Matsuzaki, Yumi
AU - Imai, Naohiko
AU - Takase, Osamu
AU - Shimosawa, Tatsuo
AU - Okano, Hideyuki
AU - Fujita, Toshiro
N1 - Funding Information:
This work was supported by Mochida Pharmaceutical Co. Ltd., Takeda Science Foundation, a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, and a Grant of “Research on Measures for Intractable Diseases” from the Ministry of Health, Labour and Welfare.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/11/14
Y1 - 2007/11/14
N2 - Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT1) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the number of cells expressing CD45, a marker of hematopoietic system, in renal SP cells was increased in obstructed kidneys. Valsartan attenuated renal injury and the associated SP profile changes. Angiotensin AT1 receptor blockade may exert regenerative effect by preserving adult stem-like cells such as SP cells in the kidney.
AB - Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT1) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the number of cells expressing CD45, a marker of hematopoietic system, in renal SP cells was increased in obstructed kidneys. Valsartan attenuated renal injury and the associated SP profile changes. Angiotensin AT1 receptor blockade may exert regenerative effect by preserving adult stem-like cells such as SP cells in the kidney.
KW - Angiotensin
KW - Fibrosis
KW - Regeneration
KW - Renal injury
KW - Renal stem cell
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U2 - 10.1016/j.ejphar.2007.07.032
DO - 10.1016/j.ejphar.2007.07.032
M3 - Article
C2 - 17692840
AN - SCOPUS:34648847334
SN - 0014-2999
VL - 573
SP - 216
EP - 220
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 1-3
ER -