Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Ulises G. Castillo, Yoshinori Uekusa, Takehiro Nishimura, Fumiyuki Kiuchi, Morena L. Martínez, Jenny Menjívar, Junko Nakajima-Shimada, Marvin J. Núñez, Haruhisa Kikuchi

研究成果: Article査読

抄録

A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.

本文言語English
ページ(範囲)1067-1074
ページ数8
ジャーナルJournal of Natural Products
87
4
DOI
出版ステータスPublished - 2024 4月 26

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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