@article{d1d36552996545daab3879d1d8e5a198,
title = "Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain",
abstract = "The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.",
keywords = "Circadian, Gut-Brain Axis, Metabolism, Microbiome, Neurometabolism, Systems biology",
author = "Smith, {Jacob G.} and Tomoki Sato and Kohei Shimaji and Koronowski, {Kevin B.} and Paul Petrus and Marlene Cervantes and Kenichiro Kinouchi and Dominik Lutter and Dyar, {Kenneth A.} and Paolo Sassone-Corsi",
note = "Funding Information: This paper is dedicated to the memory of Paolo Sassone-Corsi, a hugely inspiring scientist and mentor. We also express gratitude to all members of the Sassone-Corsi laboratory for their support and scientific input to both the project and manuscript, and to our animal technician Shoko Sato and lab manager William Orquiz for their help. J.G.S was supported by the Zymo-CEM Postdoctoral Fellowship (Zymo Research), K.B.K was supported by NIH-NIDDK F32DK121425, K.K. was supported by a postdoctoral fellowship from the Japan Society for the Promotion of Science (JSPS), Work in the P.S.-C. lab is supported by the NIH grants R21DK114652 and R21AG053592, a Challenge Grant from the Novo Nordisk Foundation (NNF-202585). Funding Information: This paper is dedicated to the memory of Paolo Sassone-Corsi, a hugely inspiring scientist and mentor. We also express gratitude to all members of the Sassone-Corsi laboratory for their support and scientific input to both the project and manuscript, and to our animal technician Shoko Sato and lab manager William Orquiz for their help. J.G.S was supported by the Zymo-CEM Postdoctoral Fellowship (Zymo Research), K.B.K was supported by NIH - NIDDK F32DK121425 , K.K. was supported by a postdoctoral fellowship from the Japan Society for the Promotion of Science (JSPS), Work in the P.S.-C. lab is supported by the NIH grants R21DK114652 and R21AG053592 , a Challenge Grant from the Novo Nordisk Foundation ( NNF-202585 ). Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = aug,
day = "15",
doi = "10.1016/j.lfs.2022.120601",
language = "English",
volume = "303",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
}