Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats

Hiroshi Itoh; Kazuwa Nakao; Takayuki Yamada; Gotaro Shirakami; Kenji Kangawa; Naoto Minamimo; Hisayuki Matsuo; Hiroo Imura

doi:10.1016/0014-2999(88)90769-8

Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats

Hiroshi Itoh
, Kazuwa Nakao
, Takayuki Yamada
, Gotaro Shirakami
, Kenji Kangawa
, Naoto Minamimo
, Hisayuki Matsuo
, Hiroo Imura

研究成果: Article › 査読

82 被引用数 (Scopus)

抄録

The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.

本文言語	English
ページ（範囲）	193-196
ページ数	4
ジャーナル	European journal of pharmacology
巻	150
号	1-2
DOI	https://doi.org/10.1016/0014-2999(88)90769-8
出版ステータス	Published - 1988 5月 20
外部発表	はい

ASJC Scopus subject areas

薬理学

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10.1016/0014-2999(88)90769-8

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title = "Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats",

abstract = "The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.",

author = "Hiroshi Itoh and Kazuwa Nakao and Takayuki Yamada and Gotaro Shirakami and Kenji Kangawa and Naoto Minamimo and Hisayuki Matsuo and Hiroo Imura",

note = "Funding Information: The authors wish to thank Ms. H. Tabata and Ms. A. Furu for secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare'Disorders of Adrenal Hormone' Research Committee, Japan, 1987, Life Science Research Project of Institute of Physical and Chemical Research (RIKEN), Japan Tobacco Inc. and Yamanouchi Foundation for Research on Metabolic Disorders, by research grants for cardiovascular diseases ((60A-3) and (62A'-1)) from the Japanese Ministry of Health and Welfare.",

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AU - Itoh, Hiroshi

AU - Nakao, Kazuwa

AU - Yamada, Takayuki

AU - Shirakami, Gotaro

AU - Kangawa, Kenji

AU - Minamimo, Naoto

AU - Matsuo, Hisayuki

AU - Imura, Hiroo

N1 - Funding Information: The authors wish to thank Ms. H. Tabata and Ms. A. Furu for secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare'Disorders of Adrenal Hormone' Research Committee, Japan, 1987, Life Science Research Project of Institute of Physical and Chemical Research (RIKEN), Japan Tobacco Inc. and Yamanouchi Foundation for Research on Metabolic Disorders, by research grants for cardiovascular diseases ((60A-3) and (62A'-1)) from the Japanese Ministry of Health and Welfare.

PY - 1988/5/20

Y1 - 1988/5/20

N2 - The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.

AB - The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.

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Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats

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