抄録
We investigated the inhibitory effect of Juzen-taiho--o in an experimental liver metastasis model, by means of inoculation of a highly liver-metastatic variant (L5) of murine colon 26 carcinoma cells into the portal vein. Oral administration of Juzen-taiho-to before tumor inoculation resulted in the dosedependent inhibition of liver tumor colonies. Oral administration of Juzen-taiho-to for 7 days before tumor inoculation led to a significant reduction in the number of metastatic colonies and liver weight even in NK-depleted mice as well as normal mice, but not in macrophage- deficient mice. This finding shows that the inhibition of metastasis by Juzen-taiho-to is associated with macrophage function.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 187-189 |
| ページ数 | 3 |
| ジャーナル | Biotherapy |
| 巻 | 12 |
| 号 | 1 |
| 出版ステータス | Published - 1998 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究
