TY - JOUR
T1 - Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H
T2 - Chemistry and biology
AU - Yamada, Kiyoyuki
AU - Ojika, Makoto
AU - Kigoshi, Hideo
AU - Suenaga, Kiyotake
PY - 2009
Y1 - 2009
N2 - Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure-activity relationships, and the three-dimensional X-ray structure of the actin-aplyronine A complex.
AB - Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure-activity relationships, and the three-dimensional X-ray structure of the actin-aplyronine A complex.
UR - http://www.scopus.com/inward/record.url?scp=58149098544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149098544&partnerID=8YFLogxK
U2 - 10.1039/b800263k
DO - 10.1039/b800263k
M3 - Review article
C2 - 19374121
AN - SCOPUS:58149098544
SN - 0265-0568
VL - 26
SP - 27
EP - 43
JO - Natural Product Reports
JF - Natural Product Reports
IS - 1
ER -
