TY - JOUR
T1 - Application of mesenchymal stem cell therapy and inner ear regeneration for hearing loss
T2 - A review
AU - Kanzaki, Sho
AU - Toyoda, Masashi
AU - Umezawa, Akihiro
AU - Ogawa, Kaoru
N1 - Funding Information:
Funding: This research is supported by a Grant-in-Aid for Scientific Research© (grant number 19K09855) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/8/2
Y1 - 2020/8/2
N2 - Inner and middle ear disorders are the leading cause of hearing loss, and are said to be among the greatest risk factors of dementia. The use of regenerative medicine for the treatment of inner ear disorders may offer a potential alternative to cochlear implants for hearing recovery. In this paper, we reviewed recent research and clinical applications in middle and inner ear regeneration and cell therapy. Recently, the mechanism of inner ear regeneration has gradually been elucidated. “Inner ear stem cells,” which may be considered the precursors of various cells in the inner ear, have been discovered in the cochlea and vestibule. Research indicates that cells such as hair cells, neurons, and spiral ligaments may form promising targets for inner ear regenerative therapies by the transplantation of stem cells, including mesenchymal stem cells. In addition, it is necessary to develop tests for the clinical monitoring of cell transplantation. Real-time imaging techniques and hearing rehabilitation techniques are also being investigated, and cell therapy has found clinical application in cochlear implant techniques.
AB - Inner and middle ear disorders are the leading cause of hearing loss, and are said to be among the greatest risk factors of dementia. The use of regenerative medicine for the treatment of inner ear disorders may offer a potential alternative to cochlear implants for hearing recovery. In this paper, we reviewed recent research and clinical applications in middle and inner ear regeneration and cell therapy. Recently, the mechanism of inner ear regeneration has gradually been elucidated. “Inner ear stem cells,” which may be considered the precursors of various cells in the inner ear, have been discovered in the cochlea and vestibule. Research indicates that cells such as hair cells, neurons, and spiral ligaments may form promising targets for inner ear regenerative therapies by the transplantation of stem cells, including mesenchymal stem cells. In addition, it is necessary to develop tests for the clinical monitoring of cell transplantation. Real-time imaging techniques and hearing rehabilitation techniques are also being investigated, and cell therapy has found clinical application in cochlear implant techniques.
KW - Hearing loss
KW - Imaging
KW - Inner ear
KW - Mesenchymal stem cells
KW - Regeneration
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U2 - 10.3390/ijms21165764
DO - 10.3390/ijms21165764
M3 - Review article
C2 - 32796705
AN - SCOPUS:85089470504
SN - 1661-6596
VL - 21
SP - 1
EP - 15
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 16
M1 - 5764
ER -