Application of microRNA in the treatment and diagnosis of cervical cancer

Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Kanako Nakamura, Masataka Adachi, Takashi Iwata, Kyoko Tanaka, Daisuke Aoki

研究成果: Chapter


MicroRNAs (miRNAs) are small non-coding RNA molecules of 20-23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.

ホスト出版物のタイトルMicroRNA Targeted Cancer Therapy
出版社Springer International Publishing
ISBN(印刷版)3319051334, 9783319051338
出版ステータスPublished - 2014 2月 1

ASJC Scopus subject areas

  • 医学一般


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