Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen

Mathematics

• Pharmacokinetics 66%
• Genotype 63%
• Predict 50%
• Modeling 35%
• End point 29%
• Dose 29%
• Efficacy 28%
• Japan 17%
• Population Size 14%
• Clinical Trials 12%
• Completion 12%
• Demonstrate 8%
• Standards 7%
• Model 4%

Medicine & Life Sciences

• Cytochrome P-450 CYP2D6 68%
• Tamoxifen 57%
• Pharmacokinetics 40%
• Genotype 38%
• Clinical Studies 37%
• 4-hydroxy-N-desmethyltamoxifen 15%
• Population Density 10%
• Japan 7%
• Clinical Trials 5%
• Therapeutics 4%

Engineering & Materials Science

• Cytochrome P-450 Enzyme System 100%
• Pharmacokinetics 76%
• Metabolites 24%
• Population Density 21%