@article{a656770bf4bf4aabadb6354535805386,
title = "Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling",
abstract = "Human",
keywords = "Human Metabolism, Microbiome",
author = "Anna Nakamura and Yoko Yokoyama and Kazuki Tanaka and Giorgia Benegiamo and Akiyoshi Hirayama and Qi Zhu and Naho Kitamura and Taichi Sugizaki and Kohkichi Morimoto and Hiroshi Itoh and Shinji Fukuda and Johan Auwerx and Kazuo Tsubota and Mitsuhiro Watanabe",
note = "Funding Information: We thank Dr. Setsuo Takekawa at Shonan Keiiku Hospital and Dr. Masaru Tomita at Institute for Advanced Biosciences (IAB), Keio University for providing continuous support. We also thank Dr. Tetsuya Hirata, Yoko Takashina, Dr. Sansho Nishibe and Dr. Aw Wanping for helpful discussion. We would like to thank Yuka Ohara and Mitsuko Komatsu and Dr. Chiharu Ishii for providing technical support for metabolome and microbiome analysis. In addition, we would like to express our gratitude to Narumi Hanazato and Naoya Nakagawa for their continuous support. This study was supported in part by JSPS KAKENHI ( JP16H05292 to M.W.; JP19K11751 to Y.Y.), Taikichiro Mori Memorial Research Grants (to A.N.), the Ryoichi Sasakawa Young Leaders Fellowship Fund (to A.N.), JSPS KAKENHI ( 18H04805 to S.F.), JST PRESTO ( JPMJPR1537 to S.F.), AMED - CREST ( JP19gm1010009 to S.F.), JST ERATO ( JPMJER1902 to S.F.), the Takeda Science Foundation (to S.F.), the Food Science Institute Foundation (to S.F.), and the Program for the Advancement of Research in Core Projects under Keio University 's Longevity Initiative (to S.F., H.I., K.Tsubota, and M.W.). The work in J.A. laboratory was supported by grants from Ecole Polytechnique Federale de Lausanne ( EPFL ), the European Research Council ( ERC-AdG-787702 to J.A.), and the Swiss National Science Foundation ( SNSF 31003A_179435 to J.A.). Funding Information: We thank Dr. Setsuo Takekawa at Shonan Keiiku Hospital and Dr. Masaru Tomita at Institute for Advanced Biosciences (IAB), Keio University for providing continuous support. We also thank Dr. Tetsuya Hirata, Yoko Takashina, Dr. Sansho Nishibe and Dr. Aw Wanping for helpful discussion. We would like to thank Yuka Ohara and Mitsuko Komatsu and Dr. Chiharu Ishii for providing technical support for metabolome and microbiome analysis. In addition, we would like to express our gratitude to Narumi Hanazato and Naoya Nakagawa for their continuous support. This study was supported in part by JSPS KAKENHI (JP16H05292 to M.W.; JP19K11751 to Y.Y.), Taikichiro Mori Memorial Research Grants (to A.N.), the Ryoichi Sasakawa Young Leaders Fellowship Fund (to A.N.), JSPS KAKENHI (18H04805 to S.F.), JST PRESTO (JPMJPR1537 to S.F.), AMED-CREST (JP19gm1010009 to S.F.), JST ERATO (JPMJER1902 to S.F.), the Takeda Science Foundation (to S.F.), the Food Science Institute Foundation (to S.F.), and the Program for the Advancement of Research in Core Projects under Keio University's Longevity Initiative (to S.F. H.I. K.Tsubota, and M.W.). The work in J.A. laboratory was supported by grants from Ecole Polytechnique Federale de Lausanne (EPFL), the European Research Council (ERC-AdG-787702 to J.A.), and the Swiss National Science Foundation (SNSF 31003A_179435 to J.A.). The study was conceived and designed by A.N. and M.W. A.N. Y.Y. K.Tanaka, G.B. Q.Z. N.K. T.S. and K.M. performed experiments. K.Tanaka, A.H. and S.F. conducted microbiome and metabolome analyses. A.N. G.B. H.I. M.W. and J.A. wrote the manuscript, and all authors gave critical comments on it. K.Tsubota. and M.W. are the guarantors of this study and, as such, had complete access to all study data and take responsibility for the integrity of the data and accuracy of the data analysis. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = sep,
day = "25",
doi = "10.1016/j.isci.2020.101522",
language = "English",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "9",
}
