Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury

Zijian Lou; Alex Post; Narihito Nagoshi; James Hong; Nader Hejrati; Jonathon Chon Teng Chio; Mohamad Khazaei; Michael G. Fehlings

doi:10.1093/stcltm/szae090

Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury

Zijian Lou
, Alex Post
, Narihito Nagoshi
, James Hong
, Nader Hejrati
, Jonathon Chon Teng Chio
, Mohamad Khazaei
, Michael G. Fehlings

整形外科学

研究成果: Article › 査読

3 被引用数 (Scopus)

抄録

Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.

本文言語	English
論文番号	szae090
ジャーナル	Stem Cells Translational Medicine
巻	14
号	2
DOI	https://doi.org/10.1093/stcltm/szae090
出版ステータス	Published - 2025 2月 1

ASJC Scopus subject areas

発生生物学
細胞生物学

文献へのアクセス

10.1093/stcltm/szae090

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引用スタイル

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AU - Hejrati, Nader

AU - Chio, Jonathon Chon Teng

AU - Khazaei, Mohamad

AU - Fehlings, Michael G.

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