TY - JOUR
T1 - Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects
AU - Miyaki, Koichi
AU - Lwin, Htay
AU - Masaki, Katsunori
AU - Song, Yixuan
AU - Takahashi, Yoshimitsu
AU - Muramatsu, Masaaki
AU - Nakayama, Takeo
PY - 2009/3
Y1 - 2009/3
N2 - This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
AB - This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
KW - Alad gene
KW - Blood lead level
KW - Environmentally lead exposure
KW - Japanese
UR - http://www.scopus.com/inward/record.url?scp=67649233791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649233791&partnerID=8YFLogxK
U2 - 10.3390/ijerph6030999
DO - 10.3390/ijerph6030999
M3 - Article
C2 - 19440429
AN - SCOPUS:67649233791
SN - 1661-7827
VL - 6
SP - 999
EP - 1009
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 3
ER -
