TY - JOUR
T1 - Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages
AU - Hirata, Takumi
AU - Arai, Yasumichi
AU - Yuasa, Shinsuke
AU - Abe, Yukiko
AU - Takayama, Michiyo
AU - Sasaki, Takashi
AU - Kunitomi, Akira
AU - Inagaki, Hiroki
AU - Endo, Motoyoshi
AU - Morinaga, Jun
AU - Yoshimura, Kimio
AU - Adachi, Tetsuo
AU - Oike, Yuichi
AU - Takebayashi, Toru
AU - Okano, Hideyuki
AU - Hirose, Nobuyoshi
N1 - Funding Information:
The authors thank the participants; Ms. Miho Shimura for assistance in participants’ recruitment. The list of investigators who participated in the TCS, JSS, or TOOTH but did not meet the author’s criteria is shown in Supplementary Note 1. This study was supported by a grant from the Ministry of Health, Welfare, and Labour for the Scientific Research Project for Longevity; a Grant-in-Aid for Scientific Research (No 23617024, 21590775, 15KT0009) from the Japan Society for the Promotion of Science; the Program for Initiative Research Projects from Keio University and Keio University Global Research Institute (KGRI), the Program for an Integrated Database of Clinical and Genomic Information (JP16kk0205009) and the Platform Program for Promotion of Genome Medicine (JP17km0405103) from Japan Agency for Medical Research and Development; and the Medical-Welfare-Food-Agriculture Collaborative Consortium Project from the Japan Ministry of Agriculture, Forestry, and Fisheries.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Supercentenarians (those aged ≥110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105–109 years), 288 centenarians (100–104 years), and 531 very old people (85–99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity.
AB - Supercentenarians (those aged ≥110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105–109 years), 288 centenarians (100–104 years), and 531 very old people (85–99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity.
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U2 - 10.1038/s41467-020-17636-0
DO - 10.1038/s41467-020-17636-0
M3 - Article
C2 - 32732919
AN - SCOPUS:85088841335
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 3820
ER -
