TY - JOUR
T1 - Asymmetric decarboxylation of disubstituted malonic acid by alcaligenes bronchisepticus KU 1201
AU - Miyamoto, Kenji
AU - Ohta, Hiromichi
N1 - Funding Information:
The authors are grateful for the financial support from Petroleum Energy Center.
PY - 1991
Y1 - 1991
N2 - Optically active αarylpropionic acids constitute a group which involves many useful compounds. We selected a microorganism which has the ability to realize the asymmetric decarboxylation of αmethyl-αphenylmalonic acid to afford optically active αphenylpropionic acid and it identified as Alcaligenes bronchisepticus KU 1201. When the aryl group was phenyl, 4-chlorophenyl, 6-methoxy-2-naphthyl or 2-thienyl, the substrate afforded optically active αarylpropionic acid in high optical and chemical yield.
AB - Optically active αarylpropionic acids constitute a group which involves many useful compounds. We selected a microorganism which has the ability to realize the asymmetric decarboxylation of αmethyl-αphenylmalonic acid to afford optically active αphenylpropionic acid and it identified as Alcaligenes bronchisepticus KU 1201. When the aryl group was phenyl, 4-chlorophenyl, 6-methoxy-2-naphthyl or 2-thienyl, the substrate afforded optically active αarylpropionic acid in high optical and chemical yield.
KW - Alcaligenes bronchisepticus.
KW - Asymmetric decarboxylation
KW - Disubstituted malonic acid
KW - αarylpropionic acid
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U2 - 10.3109/10242429109014854
DO - 10.3109/10242429109014854
M3 - Article
AN - SCOPUS:0002536129
SN - 1024-2422
VL - 5
SP - 49
EP - 60
JO - Biocatalysis and Biotransformation
JF - Biocatalysis and Biotransformation
IS - 1
ER -