Asymmetric synthesis of syn- and anti-1,3-amino alcohols

Takuya Kochi; Tony P. Tang; Jonathan A. Ellman

doi:10.1021/ja026292g

Asymmetric synthesis of syn- and anti-1,3-amino alcohols

Takuya Kochi
, Tony P. Tang
, Jonathan A. Ellman

研究成果: Article › 査読

145 被引用数 (Scopus)

抄録

The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. Reduction of the β-hydroxy-N-sulfinyl imine products with catecholborane and LiBHEt₃ provides syn- and anti-1,3-amino alcohol derivatives, respectively, with very high diastereomeric ratios.

本文言語	English
ページ（範囲）	6518-6519
ページ数	2
ジャーナル	Journal of the American Chemical Society
巻	124
号	23
DOI	https://doi.org/10.1021/ja026292g
出版ステータス	Published - 2002 6月 12
外部発表	はい

ASJC Scopus subject areas

触媒
化学一般
生化学
コロイド化学および表面化学

文献へのアクセス

10.1021/ja026292g

他のファイルとリンク

引用スタイル

@article{19181fb7d62f4162bff06197a637685d,

title = "Asymmetric synthesis of syn- and anti-1,3-amino alcohols",

abstract = "The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. Reduction of the β-hydroxy-N-sulfinyl imine products with catecholborane and LiBHEt3 provides syn- and anti-1,3-amino alcohol derivatives, respectively, with very high diastereomeric ratios.",

author = "Takuya Kochi and Tang, \{Tony P.\} and Ellman, \{Jonathan A.\}",

year = "2002",

month = jun,

day = "12",

doi = "10.1021/ja026292g",

language = "English",

volume = "124",

pages = "6518--6519",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "23",

}

TY - JOUR

T1 - Asymmetric synthesis of syn- and anti-1,3-amino alcohols

AU - Kochi, Takuya

AU - Tang, Tony P.

AU - Ellman, Jonathan A.

PY - 2002/6/12

Y1 - 2002/6/12

N2 - The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. Reduction of the β-hydroxy-N-sulfinyl imine products with catecholborane and LiBHEt3 provides syn- and anti-1,3-amino alcohol derivatives, respectively, with very high diastereomeric ratios.

AB - The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. Reduction of the β-hydroxy-N-sulfinyl imine products with catecholborane and LiBHEt3 provides syn- and anti-1,3-amino alcohol derivatives, respectively, with very high diastereomeric ratios.

UR - https://www.scopus.com/pages/publications/0037067015

UR - https://www.scopus.com/pages/publications/0037067015#tab=citedBy

U2 - 10.1021/ja026292g

DO - 10.1021/ja026292g

M3 - Article

C2 - 12047156

AN - SCOPUS:0037067015

SN - 0002-7863

VL - 124

SP - 6518

EP - 6519

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 23

ER -

Asymmetric synthesis of syn- and anti-1,3-amino alcohols

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル