Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla

Maarit Heino, Pärt Peterson, Jun Kudoh, Kentaro Nagamine, Anssi Lagerstedt, Vladimir Ovod, Annamari Ranki, Immo Rantala, Markku Nieminen, Juha Tuukkanen, Hamish S. Scott, Stylianos E. Antonarakis, Nobuyoshi Shimizu, Kai Krohn

研究成果: Article査読

239 被引用数 (Scopus)


The AIRE gene (autoimmune regulator), coding for a putative transcriptional regulatory factor, is mutated in autoimmune-polyendocrinopathy-candidiasis ectodermal dystrophy (APECED). We have investigated the expression of the AIRE gene by mRNA in situ hybridization and immunohistochemistry in various human tissues. Here we show that AIRE is expressed in distinct cells in thymus medulla, and also in rare cells in lymph node paracortex and medulla, and in spleen and fetal liver, but not in the target organs of autoimmune destruction. Double immunofluorescence studies revealed that in thymus medulla both epithelial (cytokeratin positive) and non-epithelial cells expressed AIRE. Subcellularly, AIRE was localised in nuclear dots in thymus and lymph node and also in transfected cells. The cellular localisation of AIRE and its nuclear localisation, compatible with its predicted protein domains, suggest that AlRE may regulate the mechanisms involved in the induction and maintenance of immune tolerance.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 1999 4月 21

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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