Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging

Miki Kohei; Naoki Takizawa; Ryosuke Tsutsumi; Wei Xu; Naoya Kumagai

doi:10.1039/d3ob00049d

Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging

Miki Kohei
, Naoki Takizawa
, Ryosuke Tsutsumi
, Wei Xu
, Naoya Kumagai

薬科学科

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded orthotetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photo-quenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.

本文言語	English
ページ（範囲）	2889-2893
ページ数	5
ジャーナル	Organic and Biomolecular Chemistry
巻	21
号	14
DOI	https://doi.org/10.1039/d3ob00049d
出版ステータス	Published - 2023 1月 30

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1039/d3ob00049d

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abstract = "The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded orthotetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photo-quenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.",

author = "Miki Kohei and Naoki Takizawa and Ryosuke Tsutsumi and Wei Xu and Naoya Kumagai",

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AU - Kohei, Miki

AU - Takizawa, Naoki

AU - Tsutsumi, Ryosuke

AU - Xu, Wei

AU - Kumagai, Naoya

PY - 2023/1/30

Y1 - 2023/1/30

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AB - The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded orthotetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photo-quenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.

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JO - Organic and Biomolecular Chemistry

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IS - 14

ER -

Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging

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