Bile acids and esophageal cancer

Juntaro Matsuzaki, Hidekazu Suzuki

研究成果: Chapter

1 被引用数 (Scopus)

抄録

The incidence rates of esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, have increased considerably in Western countries. Duodenogastroesophageal bile reflux is the major cause of this disease. Bile acids induce cytotoxicity in the esophageal epithelium through production of reactive oxygen species and activation of nuclear factor-kB and its downstream signaling pathways. Recent studies have revealed the characteristics of bile acid receptors and transporters in Barrett's esophagus and esophageal adenocarcinoma.

本文言語English
ホスト出版物のタイトルBile Acids in Gastroenterology
ホスト出版物のサブタイトルBasic and Clinical
出版社Springer Japan
ページ177-184
ページ数8
ISBN(電子版)9784431560623
ISBN(印刷版)9784431560609
DOI
出版ステータスPublished - 2017 4月 3

ASJC Scopus subject areas

  • 医学一般

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