Biodosimetry of heavy ions by interphase chromosome painting

M. Durante, T. Kawata, T. Nakano, S. Yamada, H. Tsujii

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We report measurements of chromosomal aberrations in peripheral blood lymphocytes from cancer patients undergoing radiotherapy treatment. Patients with cervix or esophageal cancer were treated with 10 MV X-rays produced at a LINAC accelerator, or high-energy carbon ions produced at the HIMAC accelerator at the National Institute for Radiological Sciences (NIRS) in Chiba. Blood samples were obtained before, during, and after the radiation treatment. Chromosomes were prematurely condensed by incubation in calyculin A. Aberrations in chromosomes 2 and 4 were scored after fluorescence in situ hybridization with whole-chromosome probes. Pre-treatment samples were exposed in vitro to X-rays, individual dose-response curves for the induction of chromosomal aberrations were determined, and used as calibration curves to calculate the effective whole-body dose absorbed during the treatment. This calculated dose, based on the calibration curve relative to the induction of reciprocal exchanges, has a sharp increase after the first few fractions of the treatment, then saturates at high doses. Although carbon ions are 2-3 times more effective than X-rays in tumor sterilization, the effective dose was similar to that of X-ray treatment. However, the frequency of complex-type chromosomal exchangeswas much higher for patients treated with carbon ions than X-ray.

本文言語English
ページ(範囲)1653-1662
ページ数10
ジャーナルAdvances in Space Research
22
12
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 航空宇宙工学
  • 天文学と天体物理学
  • 地球物理学
  • 大気科学
  • 宇宙惑星科学
  • 地球惑星科学一般

フィンガープリント

「Biodosimetry of heavy ions by interphase chromosome painting」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル