TY - GEN
T1 - Biohybrid neural probe
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
AU - Okita, Keisuke
AU - Kato-Negishi, Midori
AU - Onoe, Hiroaki
AU - Gojo, Riho
AU - Teshima, Tetsuhiko
AU - Takeuchi, Shoji
PY - 2011/12/1
Y1 - 2011/12/1
N2 - We propose a neural probe combined with a neuronal spheroid (neurospheroid) cultured on electrodes for deep brain stimulation. Since neurons of the spheroid extend their axons deep into the brain tissue, the neural probe can electrically stimulate deep brain area via the neurons without inserting an invasive probe. Here we first fabricated an electrode and then successfully placed a neurospheorid at the electrodes tip, named a "biohybrid neural probe". Furthermore, we tried to make the fabricated probe contact with cultured cortical cells on glass. We believe that our biohybrid neural probe has a potential to provide minimally invasive stimulation to the brain tissue.
AB - We propose a neural probe combined with a neuronal spheroid (neurospheroid) cultured on electrodes for deep brain stimulation. Since neurons of the spheroid extend their axons deep into the brain tissue, the neural probe can electrically stimulate deep brain area via the neurons without inserting an invasive probe. Here we first fabricated an electrode and then successfully placed a neurospheorid at the electrodes tip, named a "biohybrid neural probe". Furthermore, we tried to make the fabricated probe contact with cultured cortical cells on glass. We believe that our biohybrid neural probe has a potential to provide minimally invasive stimulation to the brain tissue.
KW - Deep brain stimulation
KW - Electrode
KW - Neural probe
KW - Neurospheroid
KW - Spheroid
UR - https://www.scopus.com/pages/publications/84883747491
UR - https://www.scopus.com/pages/publications/84883747491#tab=citedBy
M3 - Conference contribution
AN - SCOPUS:84883747491
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 332
EP - 334
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -