Biological markers of invasive breast cancer

Akiko Matsumoto, Hiromitsu Jinno, Tomofumi Ando, Taku Fujii, Tetsuya Nakamura, Junichi Saito, Maiko Takahashi, Tetsu Hayashida, Yuko Kitagawa

研究成果: Review article査読

25 被引用数 (Scopus)


Biological markers for breast cancer are biomolecules that result from cancer-related processes and are associated with particular clinical outcomes; they thus help predict responses to therapy. In recent years, gene expression profiling has made themolecular classification of breast cancer possible. Classification of breast cancer by immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 and Ki-67 is standard practice for clinical decision- making. Assessments of hormone receptor expression and human epidermal growth factor receptor 2 overexpression help estimate benefits from targeted therapies and have greatly improved prognoses for women with these breast cancer types. Although Ki-67 positivity is associated with an adverse outcome, its clear identification is an aid to optimal disease management. Standardization of testingmethodology to minimize inter-laboratory measurement variations is a remaining issue.Multigene assays provide prognostic information and identify those most likely to benefit from systemic chemotherapy. Incorporating molecular profiles with conventional pathological classification would bemore precise, and could enhance the clinical development of personalized therapy in breast cancer.

ジャーナルJapanese journal of clinical oncology
出版ステータスPublished - 2016 2月 1

ASJC Scopus subject areas

  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究


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