Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium

Arihiro Iwasaki; Takato Tadenuma; Shimpei Sumimoto; Taichi Ohshiro; Kaori Ozaki; Keisuke Kobayashi; Toshiaki Teruya; Hiroshi Tomoda; Kiyotake Suenaga

doi:10.1021/acs.jnatprod.7b00137

Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium

Arihiro Iwasaki
, Takato Tadenuma
, Shimpei Sumimoto
, Taichi Ohshiro
, Kaori Ozaki
, Keisuke Kobayashi
, Toshiaki Teruya
, Hiroshi Tomoda
, Kiyotake Suenaga

化学科

研究成果: Article › 査読

21 被引用数 (Scopus)

抄録

Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.

本文言語	English
ページ（範囲）	1161-1166
ページ数	6
ジャーナル	Journal of Natural Products
巻	80
号	4
DOI	https://doi.org/10.1021/acs.jnatprod.7b00137
出版ステータス	Published - 2017 4月 28

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

SDG 3 すべての人に健康と福祉を
SDG 14 海の豊かさを守ろう

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/acs.jnatprod.7b00137

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title = "Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium",

abstract = "Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.",

author = "Arihiro Iwasaki and Takato Tadenuma and Shimpei Sumimoto and Taichi Ohshiro and Kaori Ozaki and Keisuke Kobayashi and Toshiaki Teruya and Hiroshi Tomoda and Kiyotake Suenaga",

note = "Funding Information: We are grateful to Prof. L. L. Rudel (Wake Forest University, Winston-Salem, NC, USA) for kindly providing SOAT1-CHO and SOAT2-CHO cells. This work was supported by JSPS KAKENHI Grant Number 16H03285 and the Naito Foundation.",

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doi = "10.1021/acs.jnatprod.7b00137",

language = "English",

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T1 - Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium

AU - Iwasaki, Arihiro

AU - Tadenuma, Takato

AU - Sumimoto, Shimpei

AU - Ohshiro, Taichi

AU - Ozaki, Kaori

AU - Kobayashi, Keisuke

AU - Teruya, Toshiaki

AU - Tomoda, Hiroshi

AU - Suenaga, Kiyotake

N1 - Funding Information: We are grateful to Prof. L. L. Rudel (Wake Forest University, Winston-Salem, NC, USA) for kindly providing SOAT1-CHO and SOAT2-CHO cells. This work was supported by JSPS KAKENHI Grant Number 16H03285 and the Naito Foundation.

PY - 2017/4/28

Y1 - 2017/4/28

N2 - Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.

AB - Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.

UR - https://www.scopus.com/pages/publications/85018408637

UR - https://www.scopus.com/pages/publications/85018408637#tab=citedBy

U2 - 10.1021/acs.jnatprod.7b00137

DO - 10.1021/acs.jnatprod.7b00137

M3 - Article

C2 - 28294609

AN - SCOPUS:85018408637

SN - 0163-3864

VL - 80

SP - 1161

EP - 1166

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium

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ASJC Scopus subject areas

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