Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells

Iyuki Namekata, Noriko Tsuruoka, Yayoi Tsuneoka, Tomoyuki Matsuda, Akira Takahara, Yoshio Tanaka, Takeshi Suzuki, Tetsuo Takahashi, Naoko Iida-Tanaka, Hikaru Tanaka

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

本文言語English
ページ(範囲)153-155
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
34
1
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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