Bone marrow-derived mesenchymal stem cells enhance bone marrow regeneration in dental extraction sockets

Takayuki Mashimo, Yukio Sato, Daisuke Akita, Taku Toriumi, Shunsuke Namaki, Yumi Matsuzaki, Yoshiyuki Yonehara, Masaki Honda

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Bone marrow-derived mesenchymal stem cells (BMMSCs) remain the most widely used source of osteogenic cells in bone tissue engineering research. A cell-based treatment for alveolar ridge augmentation has received attention as an alternative to bone grafting. In the present study, BMMSC transplantation into tooth extraction sockets of C57BL/6J mice was evaluated for alveolar ridge regeneration. The first right maxillary molars were extracted, and then BMMSCs (PDGFRα+ Sca-1+ CD45 TER119 cells) isolated from femoral and tibial bone marrow were immediately transplanted into the extraction sockets. A control group underwent the same procedure except for BMMSC transplantation. Bone formation in the sockets was evaluated using micro-computed tomography and histological and immunohisto-chemical analyses. At 3 weeks, bone formation in the sockets was more advanced in the experimental group than in the control group. Histological analysis at 6 weeks after transplantation showed that the sockets in the experimental group also contained a greater quantity of bone marrow. Interestingly, socket bone mineral density was lower in the experimental group than in the control group at 6 weeks. These findings suggest that BMMSC transplantation accelerates bone healing and augments bone marrow formation in tooth extraction sockets.

本文言語English
ページ(範囲)284-293
ページ数10
ジャーナルJournal of Oral Science
61
2
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 歯学一般

フィンガープリント

「Bone marrow-derived mesenchymal stem cells enhance bone marrow regeneration in dental extraction sockets」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル