Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

Paul D. Gottlieb, Stephanie A. Pierce, Robert J. Sims, Hiroyuki Yamagishi, Elizabeth K. Weihe, June V. Harriss, Shanna D. Maika, William A. Kuziel, Heather L. King, Eric N. Olson, Osamu Nakagawa, Deepak Srivastava

研究成果: Article査読

280 被引用数 (Scopus)

抄録

Many transcription factors regulate specific temporal-spatial events during cardiac differentiation; however, the mechanisms that regulate such events are largely unknown. Using a modified subtractive hybridization method to identify specific genes that influence early cardiac development, we found that Bop is expressed specifically in cardiac and skeletal muscle precursors before differentiation of these lineages. Bop encodes a protein containing MYND and SET domains, which have been shown to regulate transcription by mediating distinct chromatin modifications. We show that m-Bop is a histone deacetylase-dependent transcriptional repressor. Targeted deletion of Bop in mice disrupted maturation of ventricular cardiomyocytes and interfered with formation of the right ventricle. Normal expression of Hand2, a transcription factor essential for right ventricular development, in cardiomyocyte precursors is dependent upon m-Bop. These results indicate that m-Bop is essential for cardiomyocyte differentiation and cardiac morphogenesis.

本文言語English
ページ(範囲)25-32
ページ数8
ジャーナルNature genetics
31
1
DOI
出版ステータスPublished - 2002 5月
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

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