Capillary electrophoresis–mass spectrometry of hydrophilic metabolomics

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Metabolomics is defined as the comprehensive identification and quantification of small molecules that provide a holistic view of cellular metabolism. The metabolomic network is downstream of the central dogma that transfers regulatory information from the genome. The metabolomic profile, that is, concentration patterns of metabolites on metabolic pathways, can be expected to directly reflect cellular phenotype. Thus, metabolomics has been used for many biomarker discoveries for metabolic diseases, such as diabetes, myocardial infarctions, and cancers. However, there are large limitations in the measurement technologies, compared to the other omics. Currently, a single analytical methodology cannot profile whole metabolites and various methods should be used to monitor the wide range of metabolic pathways. Here, we introduce metabolomics using capillary electrophoresis-mass spectrometry which is suitable for hydrophilic metabolite quantifications.

本文言語English
ホスト出版物のタイトルNeuromethods
出版社Humana Press Inc.
ページ113-120
ページ数8
DOI
出版ステータスPublished - 2021

出版物シリーズ

名前Neuromethods
159
ISSN(印刷版)0893-2336
ISSN(電子版)1940-6045

ASJC Scopus subject areas

  • 神経科学一般
  • 生化学、遺伝学、分子生物学一般
  • 薬理学、毒性学および薬学(全般)
  • 精神医学および精神衛生

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