TY - JOUR
T1 - Catalytic, Directed C-C Bond Functionalization of Styrenes
AU - Onodera, Shunsuke
AU - Togashi, Ryo
AU - Ishikawa, Soya
AU - Kochi, Takuya
AU - Kakiuchi, Fumitoshi
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/4/22
Y1 - 2020/4/22
N2 - A method for catalytic conversion of C(aryl)-C(alkenyl) bonds in styrene derivatives to new C-C bonds is developed. In the presence of a rhodium catalyst, the alkenyl groups of styrenes bearing a pyrazolyl directing group were efficiently converted to other carbon substituents upon reacting with various alkenes including styrenes, aliphatic alkenes, and allyl alcohols. It is also indicated that the C-C bond cleavage proceeded via a hydrometalation/β-carbon elimination pathway.
AB - A method for catalytic conversion of C(aryl)-C(alkenyl) bonds in styrene derivatives to new C-C bonds is developed. In the presence of a rhodium catalyst, the alkenyl groups of styrenes bearing a pyrazolyl directing group were efficiently converted to other carbon substituents upon reacting with various alkenes including styrenes, aliphatic alkenes, and allyl alcohols. It is also indicated that the C-C bond cleavage proceeded via a hydrometalation/β-carbon elimination pathway.
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U2 - 10.1021/jacs.0c02232
DO - 10.1021/jacs.0c02232
M3 - Article
C2 - 32249570
AN - SCOPUS:85089390698
SN - 0002-7863
VL - 142
SP - 7345
EP - 7349
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 16
ER -