CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch

Masashi Ebisawa, Koji Hase, Daisuke Takahashi, Hiroshi Kitamura, Kathryn A. Knoop, Ifor R. Williams, Hiroshi Ohno

研究成果: Article査読

45 被引用数 (Scopus)


M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6hiCD11cint resided in the subepithelial dome (SED) in mouse PP. CCR6hiCD11cint B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6hiCD11cint B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6hiCD11cint B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6hiCD11cint B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.

ジャーナルInternational immunology
出版ステータスPublished - 2011 4月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学


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