@article{098ab7450b8f4a2492da3fd849fc2338,
title = "CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression",
abstract = "Cyclin-dependent kinase 12 (CDK12), one of the key factors associated with DNA damage response pathways, is located on chromosome 17 proximal to Erb-B2 receptor tyrosine kinase 2 (ERBB2). In this report, CDK12 and ERBB2 coamplification was detected by targeted next-generation sequencing in two urothelial carcinomas. The staining intensity of the CDK12 and human epidermal growth factor receptor-2 proteins was associated with the prognosis of each urothelial carcinoma case. Our results suggest that CDK12 coamplification with ERBB2 might be associated with tumor aggressiveness and contribution to cancer pathogenesis. Therapies targeting CDK12 should be developed for these patients.",
keywords = "CDK12 amplification, DNA repair gene, ERBB2, prostate cancer, urothelial carcinoma",
author = "Yoshinori Yanai and Takeo Kosaka and Kohei Nakamura and Eriko Aimono and Kazuhiro Matsumoto and Shinya Morita and Shuji Mikami and Hiroshi Nishihara and Mototsugu Oya",
note = "Funding Information: We thank Yoko Suzuki, Emmy Yanagida, and Hiroshi Yamada for technical assistance. This work was supported in part by a Grant‐in‐Aid for Scientific Research (#20H03817 to T.K) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by a research grant to T. Kosaka from the Japan Urological Association. Publisher Copyright: {\textcopyright} 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.",
year = "2020",
month = dec,
doi = "10.1111/cas.14672",
language = "English",
volume = "111",
pages = "4652--4655",
journal = "Cancer science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "12",
}
